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Interleukin-23 receptor

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Immunopharmacology Ligand Target has curated data in GtoImmuPdb

Target id: 2293

Nomenclature: Interleukin-23 receptor

Family: IL-12 receptor family

Annotation status:  image of a red circle Awaiting annotation  » Email us

Contents:

Quaternary Structure: Subunits
Interleukin-12 receptor, β1 subunit (Ligand-binding subunit)
Interleukin 23 receptor (Ligand-binding subunit)
Natural/Endogenous Ligands Click here for help
IL-23 {Sp: Human}

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Inhibitors
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Ligand Sp. Action Value Parameter Reference
icotrokinra Peptide Immunopharmacology Ligand Hs Inhibition 11.7 pKd 2
⤷ pKd 11.7 (Kd 2x10-12 M) [2]
icotrokinra Peptide Immunopharmacology Ligand Hs Inhibition 11.3 pIC50 2
⤷ pIC50 11.3 (IC50 4.7x10-12 M) [2]
Description: Measuring inhibition of IL-23-mediated signalling in human T cells
Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IL-23 {Sp: Human} Peptide Immunopharmacology Ligand Hs Agonist 7.4 – 10.5 pKd 1,3
⤷ pKd 10.5 (Kd 3.16x10-11 M) [3]
Description: Binding affinity (NanoBRET)
pKd 7.4 (Kd 4.4x10-8 M) [1]
Description: Determined by microcalorimetry
IL-23 {Sp: Human} Peptide Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist 9.6 pEC50 3
⤷ pEC50 9.6 (EC50 2.69x10-10 M) [3]
Description: Potency in inhbiting STAT3 phosphorylation by AlphaLISA
Immunopharmacology Comments
The functional IL-23 receptor is a heterodimer consisting of the interleukin-12 receptor, β1 subunit (IL12RB1) and the interleukin-23 receptor (IL23R).

References

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1. Bloch Y, Bouchareychas L, Merceron R, Składanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M et al.. (2018) Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1. Immunity, 48 (1): 45-58.e6. [PMID:29287995]

2. Fourie A, Cheng X, Chang L, Greving C, Patrick A, Knight B, Polidari D, Patch R, Bhandari A, Liu D. (2023) 1109 First-in-class oral peptide systemically targeting the IL-23 pathway. Journal of Investigative Dermatology, 143 (5 supplement): S190.

3. Lay CS, Bridges A, Goulding J, Briddon SJ, Soloviev Z, Craggs PD, Hill SJ. (2022) Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET. Cell Chem Biol, 29 (1): 19-29.e6. [PMID:34038748]

Citation information

Last modified on 02/09/2025.

The citation format for the published version of this page will be:

IL-12 receptor family: Interleukin-23 receptor. Last modified on 02/09/2025. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2293.