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charybdotoxin   Click here for help

GtoPdb Ligand ID: 2328

Synonyms: ChTX | ChTX-Lql
Compound class: Peptide
Comment: From Leiurus quinquestriatus hebraeus (Yellow scorpion). Functions as a blocker of select calcium-activated potassium channels (KCa) [2].
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Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kv1.3 Hs Channel blocker - 7.5 – 9.7 pKd - 1,3,9
pKd 7.5 – 9.7 [1,3,9]
Kv1.3 Rn Channel blocker - 8.6 pKd - 4
pKd 8.6 [4]
KCa3.1 Hs Channel blocker Inhibition 8.5 pKd - 3
pKd 8.5 [3]
Kv1.2 Rn Channel blocker - 7.9 pKd - 4
pKd 7.9 [4]
Kv1.6 Hs Channel blocker - 9.0 pIC50 - 5
pIC50 9.0 [5]
KCa3.1 Hs Channel blocker - 7.6 – 8.7 pIC50 - 6-7
pIC50 7.6 – 8.7 (IC50 2.8x10-8 – 2x10-9 M) [6-7]
Kv1.8 Hs Channel blocker - 7.0 pIC50 - 8
pIC50 7.0 [8]
KCa1.1 Hs Channel blocker - 6.6 pIC50 - 2
pIC50 6.6 (IC50 2.5x10-7 M) [2]