GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
Type VIII RTKs: ROR family C
Formerly known as: ROR family and other RTKs
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
ROR1 and ROR2 are involved in regulating Wnt-5a (WNT5A, P41221) signalling. There is evidence that ROR1 and ROR2 can form heteromeric complexes. Due to their role in cancer, therapies targeting RORs are under investigation. Thus, ROR1 and ROR2 appear to be activated by Wnt-5a binding to a Frizzled receptor thereby forming a cell-surface multiprotein complex [1].
Receptors
|
ROR1 (receptor tyrosine kinase like orphan receptor 1)
C
Show summary »
More detailed page |
|
ROR2 (receptor tyrosine kinase like orphan receptor 2)
C
Show summary »
More detailed page |
Further reading
Citation information
Database page citation:
Chloe J. Peach. Type VIII RTKs: ROR family . Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=332.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.
