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Not curated in GtoImmuPdb
Target id: 648
Nomenclature: 5-ht5b receptor
Family: 5-Hydroxytryptamine receptors
Annotation status:
Awaiting annotation
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Gene and Protein Information  |
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| class A G protein-coupled receptor: pseudogene in man | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | - | 2q14.1 | HTR5BP | 5-hydroxytryptamine receptor 5B, pseudogene | |
| Mouse | 7 | 370 | 1 52.98 cM | Htr5b | 5-hydroxytryptamine (serotonin) receptor 5B | |
| Rat | 7 | 370 | 13p12 | Htr5b | 5-hydroxytryptamine (serotonin) receptor 5B | |
| Gene and Protein Information Comments | ||||||
| The human orthologue of the mouse 5-ht5b receptor is non-functional due to interruption of the gene by stop codons. | ||||||
| Previous and Unofficial Names |
| GPR134 | HTR5B | G protein-coupled receptor 134 | 5Ht5b | MR22 | serotonin receptor 5B | 5-hydroxytryptamine (serotonin) receptor 5B, pseudogene |
| Database Links |
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| Specialist databases | |
| GPCRdb | 5ht5b_mouse (Mm), 5ht5b_rat (Rn) |
| Other databases | |
| Alphafold | P31387 (Mm), P35365 (Rn) |
| ChEMBL Target | CHEMBL2619 (Rn) |
| Ensembl Gene | ENSG00000125631 (Hs), ENSMUSG00000050534 (Mm), ENSRNOG00000002549 (Rn) |
| Entrez Gene | 645694 (Hs), 15564 (Mm), 79247 (Rn) |
| Human Protein Atlas | ENSG00000125631 (Hs) |
| KEGG Gene | hsa:645694 (Hs), mmu:15564 (Mm), rno:79247 (Rn) |
| RefSeq Nucleotide | NG_008325 (Hs), NM_010483 (Mm), NM_024395 (Rn) |
| RefSeq Protein | NP_077371 (Rn) |
| UniProtKB | P31387 (Mm), P35365 (Rn) |
| Wikipedia | HTR5BP (Hs) |
| Natural/Endogenous Ligands |
| 5-hydroxytryptamine |
Download all structure-activity data for this target as a CSV file 
| Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Matthes H, Boschert U, Amlaiky N, Grailhe R, Plassat JL, Muscatelli F, Mattei MG, Hen R. (1993) Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol Pharmacol, 43 (3): 313-9. [PMID:8450829]
2. Waeber C, Grailhe R, Yu XJ, Hen R, Moskowitz MA. (1998) Putative 5-ht5 receptors: localization in the mouse CNS and lack of effect in the inhibition of dural protein extravasation. Ann N Y Acad Sci, 861: 85-90. [PMID:9928243]
Nicholas M. Barnes, Rodrigo Andrade, Gordon Baxter, Joel Bockaert, Theresa Branchek, Amy Butler, Marlene L. Cohen, Aline Dumuis, Richard M. Eglen, Manfred Göthert, Mark Hamblin, Michel Hamon, Paul R. Hartig, René Hen, Julie Hensler, Katharine Herrick-Davis, Rebecca Hills, Daniel Hoyer, Patrick P. A. Humphrey, Klaus Peter Latté, Luc Maroteaux, Graeme R. Martin, Derek N. Middlemiss, Ewan Mylecharane, John Neumaier, Stephen J. Peroutka, John A. Peters, Bryan Roth, Pramod R. Saxena, Trevor Sharp, Andrew Sleight, Carlos M. Villalon, Frank Yocca.
Last modified on 01/02/2018.
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