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Target has curated data in GtoImmuPdb
Target id: 3247
Nomenclature: stabilin 1
Family: Scavenger receptors
Annotation status:
Awaiting annotation
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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 2570 | 3p21.1 | STAB1 | stabilin 1 | |
| Mouse | 1 | 2571 | 14 19.09 cM | Stab1 | stabilin 1 | |
| Rat | - | - | 16p16 | Stab1 | stabilin 1 | |
| Previous and Unofficial Names |
| CLEVER-1 | FEEL-1 | FEX1 | SCARH2 | STAB-1 |
| Database Links |
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| Alphafold | Q9NY15 (Hs) |
| Ensembl Gene | ENSG00000010327 (Hs), ENSMUSG00000042286 (Mm), ENSRNOG00000018434 (Rn) |
| Entrez Gene | 23166 (Hs), 192187 (Mm), 100363145 (Rn) |
| Human Protein Atlas | ENSG00000010327 (Hs) |
| KEGG Gene | hsa:23166 (Hs), mmu:192187 (Mm), rno:100363145 (Rn) |
| OMIM | 608560 (Hs) |
| Pharos | Q9NY15 (Hs) |
| UniProtKB | Q9NY15 (Hs) |
| Wikipedia | STAB1 (Hs) |
Download all structure-activity data for this target as a CSV file 
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| Immunopharmacology Comments |
| Stabilin-1/CLEVER-1 scavenges and clears unwanted self components, and promotes immunosuppression in the tumour microenvironment. Expression on macrophages and endothelial cells is induced during chronic inflammation. Blocking Stabilin-1 on monocytes or macrophages converts immunosuppressive M2 macrophages into immunostimulatory M1 macrophages, and this effect is being investigated as a mechanism to induce T cell-dependent killing of cancer cells [1-2]. |
1. Hollmén M, Maksimow M, Rannikko JH, Karvonen MK, Vainio M, Jalkanen S, Jalkanen M, Mandelin J. (2022) Nonclinical Characterization of Bexmarilimab, a Clever-1-Targeting Antibody for Supporting Immune Defense Against Cancers. Mol Cancer Ther, 21 (7): 1207-1218. [PMID:35500016]
2. Viitala M, Virtakoivu R, Tadayon S, Rannikko J, Jalkanen S, Hollmén M. (2019) Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8+ T-cell Response against Immunosuppressive Tumors. Clin Cancer Res, 25 (11): 3289-3303. [PMID:30755440]
Last modified on 29/08/2023.
The citation format for the published version of this page will be:
Scavenger receptors: stabilin 1. Last modified on 29/08/2023. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3247.
