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Not curated in GtoImmuPdb
Target id: 3217
Nomenclature: DNA gyrase subunit A
Family: Bacterial protein targets
Annotation status:
Awaiting annotation
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| Quaternary Structure: Complexes |
| DNA gyrase |
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Escherichia coli | - | 875 | gyrA | DNA gyrase subunit A | ||
| Database Links |
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| Alphafold | P0AES4 (E.coli) |
| ChEMBL Target | CHEMBL1858 (E.coli) |
| Entrez Gene | 946614 (E.coli) |
| RefSeq Protein | NP_416734 (E.coli) |
| UniProtKB | P0AES4 (E.coli) |
| Selected 3D Structures |
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Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| General Comments |
| DNA gyrase subunit A is comprised of an N-terminal domain (59-64 kDa) involved in DNA cleavage and ligation, and a C-terminal domain (33 kDa) involved in DNA-protein interactions [4]. |
1. Bakker AT, Kotsogianni I, Avalos M, Punt JM, Liu B, Piermarini D, Gagestein B, Slingerland CJ, Zhang L, Willemse JJ et al.. (2024) Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria. Nat Chem, 16 (9): 1462-1472. [PMID:38898213]
2. Barnard FM, Maxwell A. (2001) Interaction between DNA gyrase and quinolones: effects of alanine mutations at GyrA subunit residues Ser(83) and Asp(87). Antimicrob Agents Chemother, 45 (7): 1994-2000. [PMID:11408214]
3. Morais Cabral JH, Jackson AP, Smith CV, Shikotra N, Maxwell A, Liddington RC. (1997) Crystal structure of the breakage-reunion domain of DNA gyrase. Nature, 388 (6645): 903-6. [PMID:9278055]
4. Reece RJ, Maxwell A. (1989) Tryptic fragments of the Escherichia coli DNA gyrase A protein. J Biol Chem, 264 (33): 19648-53. [PMID:2555327]
Last modified on 22/05/2025.
The citation format for the published version of this page will be:
Bacterial protein targets: DNA gyrase subunit A. Last modified on 22/05/2025. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3217.
