Top ▲

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

FKBP prolyl isomerase 8

Click here for help

Not curated in GtoImmuPdb

Target id: 3177

Nomenclature: FKBP prolyl isomerase 8

Abbreviated Name: FKBP38

Family: Peptidyl-prolyl cis/trans isomerases

Annotation status:  image of a red circle Awaiting annotation  » Email us

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 413 19p13.11 FKBP8 FKBP prolyl isomerase 8
Mouse - 403 Ch 8, 34.15 cM, cytoband C1 Fkbp8 FK506 binding protein 8
Rat - 403 16p14 Fkbp8 FKBP prolyl isomerase 8
Previous and Unofficial Names Click here for help
K506 binding protein 8 | FKBP38 | FKBPr38 | K506-binding protein 8 (38kD)
Database Links Click here for help
Alphafold
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 5.2.1.8

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GPI-1046 Small molecule or natural product Ligand has a PDB structure Hs - 7.3 pKi 1
pKi 7.3 (Ki 4.8x10-8 M) [1]
DM-CHX Small molecule or natural product Hs - 7.1 pKi 1
pKi 7.1 (Ki 8.5x10-8 M) [1]

References

Show »

1. Edlich F, Weiwad M, Wildemann D, Jarczowski F, Kilka S, Moutty MC, Jahreis G, Lücke C, Schmidt W, Striggow F et al.. (2006) The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia. J Biol Chem, 281 (21): 14961-70. [PMID:16547004]

Contributors

Show »

Citation information

Stephanie Annett, Tracy Robson.

Last modified on 17/03/2021.

The citation format for the published version of this page will be: