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cryptochrome circadian regulator 1

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Not curated in GtoImmuPdb

Target id: 2876

Nomenclature: cryptochrome circadian regulator 1

Family: Circadian clock proteins

Annotation status:  image of a red circle Awaiting annotation  » Email us

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 586 12q23.3 CRY1 cryptochrome circadian regulator 1
Mouse - 606 10 41.63 cM Cry1 cryptochrome circadian regulator 1
Rat - 588 7q13 Cry1 cryptochrome circadian regulator 1
Previous and Unofficial Names Click here for help
cryptochrome 1 (photolyase-like) | cryptochrome circadian clock 1 | PHLL1
Database Links Click here for help
Alphafold Q16526 (Hs), P97784 (Mm), Q32Q86 (Rn)
CATH/Gene3D 3.40.50.620
ChEMBL Target CHEMBL4296246 (Hs)
Ensembl Gene ENSG00000008405 (Hs), ENSMUSG00000020038 (Mm), ENSRNOG00000006622 (Rn)
Entrez Gene 1407 (Hs), 12952 (Mm), 299691 (Rn)
Human Protein Atlas ENSG00000008405 (Hs)
KEGG Gene hsa:1407 (Hs), mmu:12952 (Mm), rno:299691 (Rn)
OMIM 601933 (Hs)
Pharos Q16526 (Hs)
RefSeq Nucleotide NM_004075 (Hs), NM_007771 (Mm), NM_198750 (Rn)
RefSeq Protein NP_004066 (Hs), NP_031797 (Mm), NP_942045 (Rn)
UniProtKB Q16526 (Hs), P97784 (Mm), Q32Q86 (Rn)
Wikipedia CRY1 (Hs)
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
KL044 Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Binding 7.2 pEC50 1
⤷ pEC50 7.2 (EC50 6.3x10-8 M) [1]

References

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1. Lee JW, Hirota T, Kumar A, Kim NJ, Irle S, Kay SA. (2015) Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem, 10 (9): 1489-97. [PMID:26174033]

Citation information

Last modified on 15/02/2021.

The citation format for the published version of this page will be:

Circadian clock proteins: cryptochrome circadian regulator 1. Last modified on 15/02/2021. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2876.