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Not curated in GtoImmuPdb
Target id: 2750
Nomenclature: DNA (cytosine-5-)-methyltransferase 3α
Family: 2.1.1.- Methyltransferases
Annotation status:
Awaiting annotation
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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 912 | 2p23.3 | DNMT3A | DNA methyltransferase 3 alpha | |
| Mouse | - | 908 | 12 A1.1 | Dnmt3a | DNA methyltransferase 3A | |
| Rat | - | 908 | 6q14 | Dnmt3a | DNA methyltransferase 3 alpha | |
| Gene and Protein Information Comments | ||||||
| Human DNMT3A has a shorter isoform of 723 amino acids. | ||||||
| Previous and Unofficial Names |
| DNA (cytosine-5-)-methyltransferase 3 alpha |
| Database Links |
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| Alphafold | Q9Y6K1 (Hs), O88508 (Mm), Q1LZ53 (Rn) |
| BRENDA | 2.1.1.37 |
| ChEMBL Target | CHEMBL1992 (Hs), CHEMBL3108652 (Mm) |
| Ensembl Gene | ENSG00000119772 (Hs), ENSMUSG00000020661 (Mm), ENSRNOG00000026649 (Rn) |
| Entrez Gene | 1788 (Hs), 13435 (Mm), 444984 (Rn) |
| Human Protein Atlas | ENSG00000119772 (Hs) |
| KEGG Enzyme | 2.1.1.37 |
| KEGG Gene | hsa:1788 (Hs), mmu:13435 (Mm), rno:444984 (Rn) |
| OMIM | 602769 (Hs) |
| Pharos | Q9Y6K1 (Hs) |
| RefSeq Nucleotide | NM_153759 (Hs), NM_022552 (Hs), NM_001271753 (Mm), NM_001003958 (Rn) |
| RefSeq Protein | NP_715640 (Hs), NP_072046 (Hs), NP_001258682 (Mm), NP_001003958 (Rn) |
| UniProtKB | Q9Y6K1 (Hs), O88508 (Mm), Q1LZ53 (Rn) |
| Wikipedia | DNMT3A (Hs) |
| Enzyme Reaction |
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| Inhibitor Comments | ||
| Azacitidine and decitabine are likely to be inhibitors of DNMT1 and DNMT3A. We infer primary target designation from reports of drug action in in vitro and in vivo studies despite the paucity of pharmacological affinity data. |
| Clinically-Relevant Mutations and Pathophysiology
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Last modified on 13/08/2015.
The citation format for the published version of this page will be:
2.1.1.- Methyltransferases: DNA (cytosine-5-)-methyltransferase 3α. Last modified on 13/08/2015. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2750.
