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Target has curated data in GtoImmuPdb
Target id: 2556
Nomenclature: Vesicular polyamine transporter
Abbreviated Name: VPAT
Systematic Nomenclature: SLC18B1
Family: SLC18 family of vesicular amine transporters
Annotation status:
Awaiting annotation
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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 12 | 456 | 6q23.2 | SLC18B1 | solute carrier family 18 member B1 | |
| Mouse | 12 | 459 | 10 A3-A4 | Slc18b1 | solute carrier family 18, subfamily B, member 1 | |
| Rat | - | - | 1p12 | Slc18b1 | solute carrier family 18 member B1 | |
| Previous and Unofficial Names |
| Solute carrier family 18 member B1 | solute carrier family 18, subfamily B, member 1 | solute carrier family 18 |
| Database Links |
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| Specialist databases | |
| Bioparadigms SLC Tables | SLC18B1 (Hs) |
| RESOLUTE | SLC18B1 (Hs) |
| Other databases | |
| Alphafold | Q6NT16 (Hs), D3Z5L6 (Mm) |
| Ensembl Gene | ENSG00000146409 (Hs), ENSMUSG00000037455 (Mm), ENSRNOG00000016371 (Rn) |
| Entrez Gene | 116843 (Hs), 309570 (Rn) |
| Human Protein Atlas | ENSG00000146409 (Hs) |
| KEGG Gene | hsa:116843 (Hs), rno:309570 (Rn) |
| OMIM | 613361 (Hs) |
| Pharos | Q6NT16 (Hs) |
| RefSeq Nucleotide | NM_052831 (Hs) |
| RefSeq Protein | NP_439896 (Hs) |
| UniProtKB | Q6NT16 (Hs), D3Z5L6 (Mm) |
| Wikipedia | SLC18B1 (Hs) |
| Substrates and Reaction Kinetics |
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| Immunopharmacology Comments |
| VPAT is expressed by mast cells and is responsible for vesicular storage of the polyamines, spermine and spermidine, in granules distinct from those containing histamine or serotonin [2]. VPAT is involved in vesicular release of these polyamines from mast cells. |
| Cell Type Associations | ||||||
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1. Hiasa M, Miyaji T, Haruna Y, Takeuchi T, Harada Y, Moriyama S, Yamamoto A, Omote H, Moriyama Y. (2014) Identification of a mammalian vesicular polyamine transporter. Sci Rep, 4: 6836. [PMID:25355561]
2. Takeuchi T, Harada Y, Moriyama S, Furuta K, Tanaka S, Miyaji T, Omote H, Moriyama Y, Hiasa M. (2017) Vesicular Polyamine Transporter Mediates Vesicular Storage and Release of Polyamine from Mast Cells. J Biol Chem, 292 (9): 3909-3918. [PMID:28082679]
Last modified on 09/03/2017.
The citation format for the published version of this page will be:
SLC18 family of vesicular amine transporters: Vesicular polyamine transporter. Last modified on 09/03/2017. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2556.
