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ubiquitin specific peptidase 2

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Not curated in GtoImmuPdb

Target id: 2430

Nomenclature: ubiquitin specific peptidase 2

Family: C19: Ubiquitin-specific protease

Annotation status:  image of a red circle Awaiting annotation  » Email us

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 605 11q23.3 USP2 ubiquitin specific peptidase 2
Mouse - 613 9 A5.1 Usp2 ubiquitin specific peptidase 2
Rat - 618 8q22 Usp2 ubiquitin specific peptidase 2
Previous and Unofficial Names Click here for help
41 kDa ubiquitin-specific protease | deubiquitinating enzyme 2 | ubiquitin carboxyl-terminal hydrolase 2 | ubiquitin specific protease 2 | ubiquitin thioesterase 2 | ubiquitin thiolesterase 2 | ubiquitin-specific-processing protease testis | Ubp41 | UBP-t
Database Links Click here for help
Specialist databases
MEROPS C19.013 (Hs)
Other databases
Alphafold O75604 (Hs), O88623 (Mm), Q5U349 (Rn)
BRENDA 3.4.19.12
ChEMBL Target CHEMBL1293227 (Hs)
Ensembl Gene ENSG00000036672 (Hs), ENSMUSG00000032010 (Mm), ENSRNOG00000006663 (Rn)
Entrez Gene 9099 (Hs), 53376 (Mm), 115771 (Rn)
Human Protein Atlas ENSG00000036672 (Hs)
KEGG Enzyme 3.4.19.12
KEGG Gene hsa:9099 (Hs), mmu:53376 (Mm), rno:115771 (Rn)
OMIM 604725 (Hs)
Pharos O75604 (Hs)
RefSeq Nucleotide NM_171997 (Hs), NM_004205 (Hs), NM_001243759 (Hs), NM_198092 (Mm), NM_016808 (Mm), NM_198091 (Mm), NM_053774 (Rn)
RefSeq Protein NP_741994 (Hs), NP_004196 (Hs), NP_001230688 (Hs), NP_932759 (Mm), NP_932760 (Mm), NP_058088 (Mm), NP_446226 (Rn)
UniProtKB O75604 (Hs), O88623 (Mm), Q5U349 (Rn)
Wikipedia USP2 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.19.12

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ML364 Small molecule or natural product Hs Inhibition 5.3 pKd 1
⤷ pKd 5.3 (Kd 5.2x10-6 M) [1]
Description: Binding affinity for hUSP2
ML364 Small molecule or natural product Hs Inhibition 6.0 pIC50 1
⤷ pIC50 6.0 (IC50 1.1x10-6 M) [1]
Description: Inhibition of USP2 de-ubiquitinating activity in vitro
MS102 Small molecule or natural product Hs Inhibition - - 1
⤷ [1]

References

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1. Dang F, Bai L, Dong J, Hu X, Wang J, Paulo JA, Xiong Y, Liang X, Sun Y, Chen Y et al.. (2023) USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice. Sci Transl Med, 15 (725): eadh7668. [PMID:38055802]

Citation information

Last modified on 12/12/2023.

The citation format for the published version of this page will be:

C19: Ubiquitin-specific protease: ubiquitin specific peptidase 2. Last modified on 12/12/2023. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2430.