Top ▲

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

tryptase gamma 1

Click here for help

Not curated in GtoImmuPdb

Target id: 2425

Nomenclature: tryptase gamma 1

Family: S1: Chymotrypsin

Annotation status:  image of a red circle Awaiting annotation  » Email us

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 321 16p13.3 TPSG1 tryptase gamma 1
Mouse 1 311 17 12.53 cM Tpsg1 tryptase gamma 1
Rat - 311 10q12 Tpsg1 tryptase gamma 1
Previous and Unofficial Names Click here for help
tryptase gamma I | Prss31 | Tmt | transmembrane tryptase | tryptase gamma II
Database Links Click here for help
Specialist databases
MEROPS S01.028 (Hs)
Other databases
Alphafold Q9NRR2 (Hs), Q9QUL7 (Mm)
BRENDA 3.4.21.-
ChEMBL Target CHEMBL4955 (Hs)
Ensembl Gene ENSG00000116176 (Hs), ENSMUSG00000033200 (Mm), ENSRNOG00000018701 (Rn)
Entrez Gene 25823 (Hs), 26945 (Mm), 302990 (Rn)
Human Protein Atlas ENSG00000116176 (Hs)
KEGG Enzyme 3.4.21.-
KEGG Gene hsa:25823 (Hs), mmu:26945 (Mm), rno:302990 (Rn)
OMIM 609341 (Hs)
Pharos Q9NRR2 (Hs)
RefSeq Nucleotide NM_012467 (Hs), NM_012034 (Mm), NM_175593 (Rn)
RefSeq Protein NP_036599 (Hs), NP_036164 (Mm), NP_783183 (Rn)
UniProtKB Q9NRR2 (Hs), Q9QUL7 (Mm)
Wikipedia TPSG1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.-

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
WX-UK1 Small molecule or natural product ? Inhibition 5.2 pKi 1
⤷ pKi 5.2 (Ki 6.3x10-6 M) [1]

References

Show »

1. Stürzebecher J, Vieweg H, Steinmetzer T, Schweinitz A, Stubbs MT, Renatus M, Wikström P. (1999) 3-Amidinophenylalanine-based inhibitors of urokinase. Bioorg Med Chem Lett, 9 (21): 3147-52. [PMID:10560742]

Citation information

Last modified on 29/07/2015.

The citation format for the published version of this page will be:

S1: Chymotrypsin: tryptase gamma 1. Last modified on 29/07/2015. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2425.