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proteasome 20S subunit beta 1

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Not curated in GtoImmuPdb

Target id: 2404

Nomenclature: proteasome 20S subunit beta 1

Family: T1: Proteasome

Annotation status:  image of a red circle Awaiting annotation  » Email us

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 241 6q27 PSMB1 proteasome 20S subunit beta 1
Mouse - 240 17 8.95 cM Psmb1 proteasome (prosome, macropain) subunit, beta type 1
Rat - 240 1q12 Psmb1 proteasome 20S subunit beta 1
Previous and Unofficial Names Click here for help
component C5 of proteasome | HC5 | Lmpc5 | macropain subunit C5 | PMSB1 | proteasome gamma chain | proteasome subunit C5 | multicatalytic endopeptidase complex subunit C5 | proteasome (prosome, macropain) subunit, beta type 1 | proteasome (prosome, macropain) subunit, beta type, 1 | proteasome (prosome | proteasome subunit beta 1
Database Links Click here for help
Specialist databases
MEROPS T01.986 (Hs)
Other databases
Alphafold P20618 (Hs), O09061 (Mm), P18421 (Rn)
BRENDA 3.4.25.1
CATH/Gene3D 3.60.20.10
ChEMBL Target CHEMBL4208 (Hs), CHEMBL4523121 (Mm)
DrugBank Target P20618 (Hs)
Ensembl Gene ENSG00000008018 (Hs), ENSMUSG00000014769 (Mm), ENSRNOG00000001488 (Rn)
Entrez Gene 5689 (Hs), 19170 (Mm), 94198 (Rn)
Human Protein Atlas ENSG00000008018 (Hs)
KEGG Enzyme 3.4.25.1
KEGG Gene hsa:5689 (Hs), mmu:19170 (Mm), rno:94198 (Rn)
OMIM 602017 (Hs)
Pharos P20618 (Hs)
RefSeq Nucleotide NM_002793 (Hs), NM_011185 (Mm), NM_053590 (Rn)
RefSeq Protein NP_002784 (Hs), NP_035315 (Mm), NP_446042 (Rn)
UniProtKB P20618 (Hs), O09061 (Mm), P18421 (Rn)
Wikipedia PSMB1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.25.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3b [PMID: 24946214] Small molecule or natural product Hs Inhibition 6.6 pKi 1
⤷ pKi 6.6 (Ki 2.4x10-7 M) [1]

References

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1. Troiano V, Scarbaci K, Ettari R, Micale N, Cerchia C, Pinto A, Schirmeister T, Novellino E, Grasso S, Lavecchia A et al.. (2014) Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors. Eur J Med Chem, 83: 1-14. [PMID:24946214]

Citation information

Last modified on 12/09/2019.

The citation format for the published version of this page will be:

T1: Proteasome: proteasome 20S subunit beta 1. Last modified on 12/09/2019. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2404.