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granzyme B

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Not curated in GtoImmuPdb

Target id: 2369

Nomenclature: granzyme B

Family: S1: Chymotrypsin

Annotation status:  image of a red circle Awaiting annotation  » Email us

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 247 14q12 GZMB granzyme B
Mouse - 247 14 28.19 cM Gzmb granzyme B
Rat - 248 15p12 Gzmb granzyme B
Previous and Unofficial Names Click here for help
cytotoxic serine protease B | CCP1 | CCP-1/C11 | CGL1 | CSPB | CTSGL1 | fragmentin | fragmentin 2 | GLP I | GLP III | GLP-1 | granzyme B(G,H) | GZB | HLP | natural killer cell protease 1 | RNKP-1 | SECT | granzyme-like protein 1 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Database Links Click here for help
Specialist databases
MEROPS S01.010 (Hs)
Other databases
Alphafold P10144 (Hs), P04187 (Mm), P18291 (Rn)
BRENDA 3.4.21.79
ChEMBL Target CHEMBL2316 (Hs)
Ensembl Gene ENSG00000100453 (Hs), ENSMUSG00000015437 (Mm), ENSRNOG00000049976 (Rn)
Entrez Gene 3002 (Hs), 14939 (Mm), 171528 (Rn)
Human Protein Atlas ENSG00000100453 (Hs)
KEGG Enzyme 3.4.21.79
KEGG Gene hsa:3002 (Hs), mmu:14939 (Mm), rno:171528 (Rn)
OMIM 123910 (Hs)
Pharos P10144 (Hs)
RefSeq Nucleotide NM_004131 (Hs), NM_013542 (Mm), NM_138517 (Rn)
RefSeq Protein NP_004122 (Hs), NP_038570 (Mm), NP_612526 (Rn)
UniProtKB P10144 (Hs), P04187 (Mm), P18291 (Rn)
Wikipedia GZMB (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.79

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 20 [PMID:12127536] Small molecule or natural product Primary target of this compound Hs Inhibition 8.1 pKi 1
⤷ pKi 8.1 (Ki 7x10-9 M) [1]

References

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1. Willoughby CA, Bull HG, Garcia-Calvo M, Jiang J, Chapman KT, Thornberry NA. (2002) Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis. Bioorg Med Chem Lett, 12 (16): 2197-200. [PMID:12127536]

Citation information

Last modified on 29/01/2016.

The citation format for the published version of this page will be:

S1: Chymotrypsin: granzyme B. Last modified on 29/01/2016. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2369.