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Target has curated data in GtoImmuPdb
Target id: 1756
Nomenclature: TLR6
Family: Toll-like receptor family
Annotation status:
Awaiting annotation
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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 796 | 4p14 | TLR6 | toll like receptor 6 | |
| Mouse | 1 | 795 | 5 33.54 cM | Tlr6 | toll-like receptor 6 | |
| Rat | - | - | 14p11 | Tlr6 | toll-like receptor 6 | |
| Previous and Unofficial Names |
| CD286 | toll-like receptor 6 |
| Database Links |
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| Alphafold | Q9Y2C9 (Hs), Q9EPW9 (Mm) |
| CATH/Gene3D | 3.40.50.10140, 3.80.10.10 |
| ChEMBL Target | CHEMBL3259477 (Hs), CHEMBL2146341 (Mm) |
| Ensembl Gene | ENSG00000174130 (Hs), ENSMUSG00000051498 (Mm), ENSRNOG00000002161 (Rn) |
| Entrez Gene | 10333 (Hs), 21899 (Mm), 305353 (Rn) |
| Human Protein Atlas | ENSG00000174130 (Hs) |
| KEGG Gene | hsa:10333 (Hs), mmu:21899 (Mm), rno:305353 (Rn) |
| OMIM | 605403 (Hs) |
| Pharos | Q9Y2C9 (Hs) |
| UniProtKB | Q9Y2C9 (Hs), Q9EPW9 (Mm) |
| Wikipedia | TLR6 (Hs) |
| Immunopharmacology Comments |
| TLR6 forms heterodimers with TLR2 to detect a wide range of bacterial lipopeptides (LP) from bacterial cell membranes, and effect an immune response [1]. TLR2/6 dimers perferentially detect diacylated LP [2]. Pam2Cys-SKKKK is a synthetic LP which induces signalling through TLR2/TLR6 heteromers. Activation of TLR2-TLR6 heteromers by LP promotes formation of a functional signalling complex that includes MyD88 and IL-1R-associated kinase (IRAK) proteins, that ultimately initiates NF-κB-mediated cytokine production. |
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| Clinically-Relevant Mutations and Pathophysiology
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1. Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, Buwitt-Beckmann U, Röschmann K, Jung G, Wiesmüller KH et al.. (2008) Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. J Leukoc Biol, 83 (3): 692-701. [PMID:18056480]
2. Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M. (2005) Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J Immunol, 174 (3): 1566-73. [PMID:15661917]
