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Target has curated data in GtoImmuPdb
Target id: 1751
Nomenclature: TLR1
Family: Toll-like receptor family
Annotation status:
Awaiting annotation
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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 786 | 4p14 | TLR1 | toll like receptor 1 | |
| Mouse | 1 | 795 | 5 33.53 cM | Tlr1 | toll-like receptor 1 | |
| Rat | - | - | 14p11 | Tlr1 | toll-like receptor 1 | |
| Previous and Unofficial Names |
| CD281 | TIL | toll-like receptor 1 | rsc786 | TIL. LPRS5 |
| Database Links |
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| Alphafold | Q15399 (Hs), Q9EPQ1 (Mm) |
| CATH/Gene3D | 3.80.10.10, 3.40.50.10140 |
| ChEMBL Target | CHEMBL3714412 (Hs), CHEMBL2146338 (Mm) |
| Ensembl Gene | ENSG00000174125 (Hs), ENSMUSG00000044827 (Mm), ENSRNOG00000038722 (Rn) |
| Entrez Gene | 7096 (Hs), 21897 (Mm), 305354 (Rn) |
| Human Protein Atlas | ENSG00000174125 (Hs) |
| KEGG Gene | hsa:7096 (Hs), mmu:21897 (Mm), rno:305354 (Rn) |
| OMIM | 601194 (Hs) |
| Pharos | Q15399 (Hs) |
| UniProtKB | Q15399 (Hs), Q9EPQ1 (Mm) |
| Wikipedia | TLR1 (Hs) |
| Immunopharmacology Comments |
| TLR1/2 heterodimers detect and respond to bacterial triacyl lipopeptides [2]. |
| Physiological Functions Comments | |
| Involved in the pro-inflammatory response to bacterial lipopeptides. |
| Clinically-Relevant Mutations and Pathophysiology
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1. Plantinga TS, Johnson MD, Scott WK, van de Vosse E, Velez Edwards DR, Smith PB, Alexander BD, Yang JC, Kremer D, Laird GM et al.. (2012) Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. J Infect Dis, 205 (6): 934-43. [PMID:22301633]
2. Uematsu S, Akira S. (2008) Toll-Like receptors (TLRs) and their ligands. Handb Exp Pharmacol, (183): 1-20. [PMID:18071652]
