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X-prolyl aminopeptidase 1

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Not curated in GtoImmuPdb

Target id: 1578

Nomenclature: X-prolyl aminopeptidase 1

Family: M24: Methionyl aminopeptidase

Annotation status:  image of a red circle Awaiting annotation  » Email us

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 623 10q25.1 XPNPEP1 X-prolyl aminopeptidase 1
Mouse - 623 19 D2 Xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Rat - 623 1q55 Xpnpep1 X-prolyl aminopeptidase 1
Previous and Unofficial Names Click here for help
Aminopeptidase P 1 | aminoacylproline aminopeptidase | cytoplasmic aminopeptidase P | sAmp | soluble aminopeptidase P | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | X-prolyl aminopeptidase (aminopeptidase P) 1
Database Links Click here for help
Specialist databases
MEROPS M24.009 (Hs)
Other databases
Alphafold Q9NQW7 (Hs), Q6P1B1 (Mm), O54975 (Rn)
BRENDA 3.4.11.9
CATH/Gene3D 3.40.350.10
ChEMBL Target CHEMBL3782 (Hs)
Ensembl Gene ENSG00000108039 (Hs), ENSMUSG00000025027 (Mm), ENSRNOG00000012084 (Rn)
Entrez Gene 7511 (Hs), 170750 (Mm), 170751 (Rn)
Human Protein Atlas ENSG00000108039 (Hs)
KEGG Enzyme 3.4.11.9
KEGG Gene hsa:7511 (Hs), mmu:170750 (Mm), rno:170751 (Rn)
OMIM 602443 (Hs)
Pharos Q9NQW7 (Hs)
RefSeq Nucleotide NM_001167604 (Hs), NM_020383 (Hs), NM_133216 (Mm), NM_131913 (Rn)
RefSeq Protein NP_065116 (Hs), NP_001161076 (Hs), NP_573479 (Mm), NP_571988 (Rn)
UniProtKB Q9NQW7 (Hs), Q6P1B1 (Mm), O54975 (Rn)
Wikipedia XPNPEP1 (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.11.9

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
apstatin Small molecule or natural product Click here for species-specific activity table Hs Inhibition 4.7 pIC50 1
⤷ pIC50 4.7 (IC50 2.1x10-5 M) [1]

References

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1. Maggiora LL, Orawski AT, Simmons WH. (1999) Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem, 42 (13): 2394-402. [PMID:10395480]

Citation information

Last modified on 18/09/2015.

The citation format for the published version of this page will be:

M24: Methionyl aminopeptidase: X-prolyl aminopeptidase 1. Last modified on 18/09/2015. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1578.