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Not curated in GtoImmuPdb
Target id: 141
Nomenclature: GPR161
Family: Class A Orphans with no pharmacology
Annotation status:
Annotated and reviewed, awaiting update
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Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 529 | 1q24.2 | GPR161 | G protein-coupled receptor 161 | |
| Mouse | 7 | 545 | 1 72.64 cM | Gpr161 | G protein-coupled receptor 161 | |
| Rat | 7 | 528 | 13q23 | Gpr161 | G protein-coupled receptor 161 | |
| Previous and Unofficial Names |
| G-protein coupled receptor RE2 |
| Database Links |
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| Specialist databases | |
| GPCRdb | gp161_human (Hs), gp161_mouse (Mm) |
| Other databases | |
| Alphafold | Q8N6U8 (Hs), B2RPY5 (Mm), F1M5Q2 (Rn) |
| ChEMBL Target | CHEMBL4523894 (Hs) |
| Ensembl Gene | ENSG00000143147 (Hs), ENSMUSG00000040836 (Mm), ENSRNOG00000003073 (Rn) |
| Entrez Gene | 23432 (Hs), 240888 (Mm), 289180 (Rn) |
| Human Protein Atlas | ENSG00000143147 (Hs) |
| KEGG Gene | hsa:23432 (Hs), mmu:240888 (Mm), rno:289180 (Rn) |
| OMIM | 612250 (Hs) |
| Pharos | Q8N6U8 (Hs) |
| RefSeq Nucleotide | NM_153832 (Hs), NM_001081126 (Mm) |
| RefSeq Protein | NP_722561 (Hs), NP_001074595 (Mm) |
| UniProtKB | Q8N6U8 (Hs), B2RPY5 (Mm), F1M5Q2 (Rn) |
| Wikipedia | GPR161 (Hs) |
| Other Binding Ligands | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Tissue Distribution
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| Expression Datasets |
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| Physiological Consequences of Altering Gene Expression Comments | |
| A C-terminal truncation (deletion) mutation in Gpr161 causes congenital cataracts and neural tube defects in the vacuolated lens (vl) mouse mutant [5]. The mutated receptor is associated with cataract, spina bifida and white belly spot phenotypes in mice [2]. GPR161 is required for right-left patterning in zebrafish development via modulation of Ca2+ in cells surrounding Kupffer's vesicles [3]. |
| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Clinically-Relevant Mutations and Pathophysiology
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| Clinically-Relevant Mutations and Pathophysiology Comments | ||||||||||||
| A C-terminal truncation (deletion) mutation in Gpr61 causes congenital cataracts and neural tube defects in the vacuolated lens (vl) mouse mutant. Foxe3 is a genetic modifier that interacts with GPR161 to regulate lens development [5]. The mutated receptor is associated with cataract, spina bifidia and white belly spot phenotypes in mice [2]. | ||||||||||||
| Gene Expression and Pathophysiology Comments | |
| Variants of GPR161 are associated with developmental disorders in man [1,6]. |
| Biologically Significant Variant Comments |
| The vacuolated lens C-terminal GPR161 truncation mutation affects receptor mediated endocytosis [5]. |
1. Kim SE, Lei Y, Hwang SH, Wlodarczyk BJ, Mukhopadhyay S, Shaw GM, Ross ME, Finnell RH. (2019) Dominant negative GPR161 rare variants are risk factors of human spina bifida. Hum Mol Genet, 28 (2): 200-208. [PMID:30256984]
2. Korstanje R, Desai J, Lazar G, King B, Rollins J, Spurr M, Joseph J, Kadambi S, Li Y, Cherry A, Matteson PG, Paigen B, Millonig JH. (2008) Quantitative trait loci affecting phenotypic variation in the vacuolated lens mouse mutant, a multigenic mouse model of neural tube defects. Physiol Genomics, 35 (3): 296-304. [PMID:18796533]
3. Leung T, Humbert JE, Stauffer AM, Giger KE, Chen H, Tsai HJ, Wang C, Mirshahi T, Robishaw JD. (2008) The orphan G protein-coupled receptor 161 is required for left-right patterning. Dev Biol, 323 (1): 31-40. [PMID:18755178]
4. Lindqvist A, Abels M, Shcherbina L, Ngara M, Kryvokhyzha D, Chriett S, Riva M, Fajul A, Barghouth M, Luan C et al.. (2023) GPR162 is a beta cell CART receptor. iScience, 26 (12): 108416. [PMID:38077141]
5. Matteson PG, Desai J, Korstanje R, Lazar G, Borsuk TE, Rollins J, Kadambi S, Joseph J, Rahman T, Wink J, Benayed R, Paigen B, Millonig JH. (2008) The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development. Proc Natl Acad Sci USA, 105 (6): 2088-93. [PMID:18250320]
6. Shimada IS, Mukhopadhyay S. (2017) G-protein-coupled receptor signaling and neural tube closure defects. Birth Defects Res, 109 (2): 129-139. [PMID:27731925]
7. Swan C, Duroudier NP, Campbell E, Zaitoun A, Hastings M, Dukes GE, Cox J, Kelly FM, Wilde J, Lennon MG et al.. (2013) Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα. Gut, 62 (7): 985-94. [PMID:22684480]
