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Not curated in GtoImmuPdb
Target id: 1366
Nomenclature: CYP26A1
Family: CYP24, CYP26 and CYP27 families
Annotation status:
Awaiting annotation
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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 497 | 10q23.33 | CYP26A1 | cytochrome P450 family 26 subfamily A member 1 | |
| Mouse | - | 497 | 19 C2 | Cyp26a1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | |
| Rat | - | - | Cyp26a1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | ||
| Previous and Unofficial Names |
| retinoic acid 4-hydroxylase | cytochrome P450, 26, retinoic acid | retinoic acid hydroxylase | cytochrome P450, family 26, subfamily A, polypeptide 1 | cytochrome P450, family 26, subfamily a, polypeptide 1 | cytochrome P450 |
| Database Links |
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| Alphafold | O43174 (Hs), O55127 (Mm) |
| BRENDA | 1.14.-.- |
| ChEMBL Target | CHEMBL5141 (Hs) |
| Ensembl Gene | ENSG00000095596 (Hs), ENSMUSG00000024987 (Mm), ENSRNOG00000016750 (Rn) |
| Entrez Gene | 1592 (Hs), 13082 (Mm), 154985 (Rn) |
| Human Protein Atlas | ENSG00000095596 (Hs) |
| KEGG Enzyme | 1.14.-.- |
| KEGG Gene | hsa:1592 (Hs), mmu:13082 (Mm), rno:154985 (Rn) |
| OMIM | 602239 (Hs) |
| Pharos | O43174 (Hs) |
| UniProtKB | O43174 (Hs), O55127 (Mm) |
| Wikipedia | CYP26A1 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Gomaa MS, Bridgens CE, Veal GJ, Redfern CP, Brancale A, Armstrong JL, Simons C. (2011) Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26). J Med Chem, 54 (19): 6803-11. [PMID:21838328]
2. Thatcher JE, Buttrick B, Shaffer SA, Shimshoni JA, Goodlett DR, Nelson WL, Isoherranen N. (2011) Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase. Mol Pharmacol, 80 (2): 228-39. [PMID:21521770]
