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Not curated in GtoImmuPdb
Target id: 1330
Nomenclature: CYP2E1
Family: CYP2 family: drug metabolising subset
Annotation status:
Awaiting annotation
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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 493 | 10q26.3 | CYP2E1 | cytochrome P450 family 2 subfamily E member 1 | |
| Mouse | - | 493 | 7 85.94 cM | Cyp2e1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | |
| Rat | - | 493 | 1q41 | Cyp2e1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | |
| Previous and Unofficial Names |
| 4-nitrophenol 2-hydroxylase | cytochrome P450 2E1 | cytochrome P450, family 2, subfamily e, polypeptide 1 | cytochrome P450, subfamily 2e1 (ethanol-inducible) | cytochrome P450, family 2, subfamily E, polypeptide 1 | cytochrome P450 |
| Database Links |
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| Alphafold | P05181 (Hs), Q05421 (Mm), P05182 (Rn) |
| BRENDA | 1.14.14.1 |
| ChEMBL Target | CHEMBL5281 (Hs), CHEMBL5978 (Rn) |
| Ensembl Gene | ENSG00000130649 (Hs), ENSMUSG00000025479 (Mm), ENSRNOG00000012458 (Rn) |
| Entrez Gene | 1571 (Hs), 13106 (Mm), 25086 (Rn) |
| Human Protein Atlas | ENSG00000130649 (Hs) |
| KEGG Enzyme | 1.14.14.1 |
| KEGG Gene | hsa:1571 (Hs), mmu:13106 (Mm), rno:25086 (Rn) |
| OMIM | 124040 (Hs) |
| Pharos | P05181 (Hs) |
| UniProtKB | P05181 (Hs), Q05421 (Mm), P05182 (Rn) |
| Wikipedia | CYP2E1 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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1. Diesinger T, Buko V, Lautwein A, Dvorsky R, Belonovskaya E, Lukivskaya O, Naruta E, Kirko S, Andreev V, Buckert D et al.. (2020) Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis. PLoS One, 15 (7): e0235990. [PMID:32701948]
2. Yano JK, Denton TT, Cerny MA, Zhang X, Johnson EF, Cashman JR. (2006) Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. J Med Chem, 49 (24): 6987-7001. [PMID:17125252]
