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Kv9.2

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Not curated in GtoImmuPdb

Target id: 568

Nomenclature: Kv9.2

Family: Voltage-gated potassium channels (Kv)

Annotation status:  image of a blue circle Annotated and reviewed, awaiting update  » Email us

Contents:

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 477 8q22.2 KCNS2 potassium voltage-gated channel modifier subfamily S member 2 1
Mouse 6 1 477 15 B3.1 Kcns2 K+ voltage-gated channel, subfamily S, 2
Rat 6 1 477 7q22 Kcns2 potassium voltage-gated channel, modifier subfamily S, member 2
Previous and Unofficial Names Click here for help
delayed-rectifier K(+) channel alpha subunit 2 | potassium voltage-gated channel, modifier subfamily S, member 2 | potassium voltage-gated channel | K+ voltage-gated channel, subfamily S, 2 | K+ voltage-gated channel
Database Links Click here for help
Alphafold Q9ULS6 (Hs), O35174 (Mm), Q9ER26 (Rn)
Ensembl Gene ENSG00000156486 (Hs), ENSMUSG00000050963 (Mm), ENSRNOG00000066111 (Rn)
Entrez Gene 3788 (Hs), 16539 (Mm), 66022 (Rn)
Human Protein Atlas ENSG00000156486 (Hs)
KEGG Gene hsa:3788 (Hs), mmu:16539 (Mm), rno:66022 (Rn)
OMIM 602906 (Hs)
Pharos Q9ULS6 (Hs)
RefSeq Nucleotide NM_020697 (Hs), NM_181317 (Mm), NM_023966 (Rn)
RefSeq Protein NP_065748 (Hs), NP_851834 (Mm), NP_076456 (Rn)
UniProtKB Q9ULS6 (Hs), O35174 (Mm), Q9ER26 (Rn)
Wikipedia KCNS2 (Hs)
Ion Selectivity and Conductance Click here for help
Species:  None
Macroscopic current rectification:  Modifiers/ Silencer
References: 
Voltage Dependence Comments
Electrically silent on its own, modulates properties of Kv2.1 in heterooligomers [3]
Tissue Distribution Click here for help
Main olfactory bulb, cerebral cortex, hippocampal formation, habenula, basolateral amygdaloid nuclei, cerebellum, retina, spinal cord.
Species:  Mouse
Technique:  RT-PCR
References:  3
Pulmonary artery, brain
Species:  Rat
Technique:  RT-PCR
References:  2
Physiological Functions Click here for help
Regulation of membrane potential and action potential frequency by modulation of delayed rectifier potassium current.
Kv9.2 modulates the activity of Kv2.1 and Kv2.2 subunits by changing kinetics and levels of expression and by shifting the half-inactivation potential to more polarized values. Kv9.1 enhances the single-channel conductance of Kv2.1.
Species:  Mouse
Tissue:  Xenopus laevis oocytes
References:  3
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Kcns2tm1Lex Kcns2tm1Lex/Kcns2tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J		 MGI:1197011  MP:0002169 no abnormal phenotype detected

References

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1. Banfi S, Borsani G, Rossi E, Bernard L, Guffanti A, Rubboli F, Marchitiello A, Giglio S, Coluccia E, Zollo M, Zuffardi O, Ballabio A. (1996) Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching. Nat Genet, 13 (2): 167-74. [PMID:8640222]

2. Davies AR, Kozlowski RZ. (2001) Kv channel subunit expression in rat pulmonary arteries. Lung, 179 (3): 147-61. [PMID:11891605]

3. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M. (1997) New modulatory alpha subunits for mammalian Shab K+ channels. J Biol Chem, 272 (39): 24371-9. [PMID:9305895]

Contributors

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Citation information

K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.

Last modified on 01/07/2010.

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