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Not curated in GtoImmuPdb
Target id: 552
Nomenclature: Kv4.1
Family: Voltage-gated potassium channels (Kv)
Annotation status:
Annotated and reviewed, awaiting update
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Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 647 | Xp11.23 | KCND1 | potassium voltage-gated channel subfamily D member 1 | 9 |
| Mouse | 6 | 1 | 651 | X 3.53 cM | Kcnd1 | potassium voltage-gated channel, Shal-related family, member 1 | 16 |
| Rat | 6 | 1 | 651 | Xq13 | Kcnd1 | potassium voltage-gated channel subfamily D member 1 | 6 |
| Previous and Unofficial Names |
| Potassium voltage-gated channel subfamily D member 1 | potassium channel, voltage gated Shal related subfamily D, member 1 | potassium channel, voltage gated Shal-related subfamily D, member 1 | potassium voltage-gated channel |
| Database Links |
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| Alphafold | Q9NSA2 (Hs), Q03719 (Mm) |
| DrugBank Target | Q9NSA2 (Hs) |
| Ensembl Gene | ENSG00000102057 (Hs), ENSMUSG00000009731 (Mm), ENSRNOG00000039544 (Rn) |
| Entrez Gene | 3750 (Hs), 16506 (Mm), 116695 (Rn) |
| Human Protein Atlas | ENSG00000102057 (Hs) |
| KEGG Gene | hsa:3750 (Hs), mmu:16506 (Mm), rno:116695 (Rn) |
| OMIM | 300281 (Hs) |
| Pharos | Q9NSA2 (Hs) |
| RefSeq Nucleotide | NM_004979 (Hs), NM_008423 (Mm), NM_001105748 (Rn) |
| RefSeq Protein | NP_004970 (Hs), NP_032449 (Mm), NP_001099218 (Rn) |
| UniProtKB | Q9NSA2 (Hs), Q03719 (Mm) |
| Wikipedia | KCND1 (Hs) |
| Associated Proteins |
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| Functional Characteristics |
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| KA | |
| Ion Selectivity and Conductance |
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| Voltage Dependence |
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| Associated subunits (Human) |
| KChIP 1-4, DP66, DPP10 |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific channel blocker tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tissue Distribution
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| Tissue Distribution Comments | ||||||||
| Also: Ferret - Brain (fetal, infant and adult), colon, heart, lung, stomach, testis, liver, kidney, thyroid gland, pancreas, pulmonary artery [4] | ||||||||
| Functional Assays
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| General Comments |
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It is a member of the mammalian Shal-related family. The Kv4.1 (KCND1) gene is encoded by at least 6 exons: the first exon encodes the protein from the N-terminus through S5 into the P-region, whereas the remainder of the protein is encoded by exons 2 - 6. The kinetic properties depend on the expression system, recording configuration, and the presence of auxiliary subunits (KChIPs). |
1. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS et al.. (2000) Modulation of A-type potassium channels by a family of calcium sensors. Nature, 403 (6769): 553-6. [PMID:10676964]
2. Beck EJ, Bowlby M, An WF, Rhodes KJ, Covarrubias M. (2002) Remodelling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein. J Physiol (Lond.), 538 (Pt 3): 691-706. [PMID:11826158]
3. Beck EJ, Covarrubias M. (2001) Kv4 channels exhibit modulation of closed-state inactivation in inside-out patches. Biophys J, 81 (2): 867-83. [PMID:11463631]
4. Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, Strauss HC. (1996) In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. Circ Res, 78 (6): 1083-9. [PMID:8635239]
5. Escoubas P, Diochot S, Célérier ML, Nakajima T, Lazdunski M. (2002) Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol Pharmacol, 62 (1): 48-57. [PMID:12065754]
6. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W et al.. (2005) International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev, 57 (4): 473-508. [PMID:16382104]
7. Harrell MD, Harbi S, Hoffman JF, Zavadil J, Coetzee WA. (2007) Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol Genomics, 28 (3): 273-83. [PMID:16985003]
8. Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME et al.. (2002) Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. Proc Natl Acad Sci USA, 99 (2): 1035-40. [PMID:11805342]
9. Isbrandt D, Leicher T, Waldschütz R, Zhu X, Luhmann U, Michel U, Sauter K, Pongs O. (2000) Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). Genomics, 64 (2): 144-54. [PMID:10729221]
10. Jerng HH, Pfaffinger PJ, Covarrubias M. (2004) Molecular physiology and modulation of somatodendritic A-type potassium channels. Mol Cell Neurosci, 27 (4): 343-69. [PMID:15555915]
11. Jerng HH, Qian Y, Pfaffinger PJ. (2004) Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Biophys J, 87 (4): 2380-96. [PMID:15454437]
12. Jerng HH, Shahidullah M, Covarrubias M. (1999) Inactivation gating of Kv4 potassium channels: molecular interactions involving the inner vestibule of the pore. J Gen Physiol, 113 (5): 641-60. [PMID:10228180]
13. Jiang B, Sun X, Cao K, Wang R. (2002) Endogenous Kv channels in human embryonic kidney (HEK-293) cells. Mol Cell Biochem, 238 (1-2): 69-79. [PMID:12349911]
14. Nadal MS, Ozaita A, Amarillo Y, Vega-Saenz de Miera E, Ma Y, Mo W, Goldberg EM, Misumi Y, Ikehara Y, Neubert TA et al.. (2003) The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels. Neuron, 37 (3): 449-61. [PMID:12575952]
15. Nakamura TY, Nandi S, Pountney DJ, Artman M, Rudy B, Coetzee WA. (2001) Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. FEBS Lett, 499 (3): 205-9. [PMID:11423117]
16. Pak MD, Baker K, Covarrubias M, Butler A, Ratcliffe A, Salkoff L. (1991) mShal, a subfamily of A-type K+ channel cloned from mammalian brain. Proc Natl Acad Sci USA, 88 (10): 4386-90. [PMID:2034678]
17. Serôdio P, Rudy B. (1998) Differential expression of Kv4 K+ channel subunits mediating subthreshold transient K+ (A-type) currents in rat brain. J Neurophysiol, 79 (2): 1081-91. [PMID:9463463]
18. Shahidullah M, Covarrubias M. (2003) The link between ion permeation and inactivation gating of Kv4 potassium channels. Biophys J, 84 (2 Pt 1): 928-41. [PMID:12547775]
K. George Chandy, Stephan Grissmer, George A. Gutman, Michel Lazdunski, David Mckinnon, Jeanne Nerbonne, Luis A. Pardo, Gail A. Robertson, Bernardo Rudy, Michael C. Sanguinetti, Walter Stühmer, Xiaoliang Wang.
Last modified on 15/09/2015.
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