The mitochondrial calcium uniporter (MCU) complex forms a highly selective channel for Ca²⁺ uptake through the the inner mitochondrial membrane [1-2]. The complex is a tetrameric structure composed of pore-forming subunits (MCU, MCUb, and Essential MCU Regulator [EMRE]) and regulatory proteins (MICU1, MICU2, and MICU3) [4,11-13]. The regulatory protein subunits control selectivity gating through the channel [9-10].

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12. Yoo J, Wu M, Yin Y, Herzik Jr MA, Lander GC, Lee SY. (2018) Cryo-EM structure of a mitochondrial calcium uniporter. Science, 361 (6401): 506-511. [PMID:29954988]

13. Zhuo W, Zhou H, Guo R, Yi J, Zhang L, Yu L, Sui Y, Zeng W, Wang P, Yang M. (2021) Structure of intact human MCU supercomplex with the auxiliary MICU subunits. Protein Cell, 12 (3): 220-229. [PMID:32862359]