Top ▲
GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
Not curated in GtoImmuPdb
Target id: 637
Nomenclature: GPR176
Family: Class A Orphans with no pharmacology
Annotation status:
Annotated and reviewed, awaiting update
» Email us
Gene and Protein Information  |
||||||
| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 515 | 15q14-q15.1 | GPR176 | G protein-coupled receptor 176 | 3 |
| Mouse | 7 | 515 | 2 E5 | Gpr176 | G protein-coupled receptor 176 | |
| Rat | 7 | 513 | 3q35 | Gpr176 | G protein-coupled receptor 176 | |
| Previous and Unofficial Names |
| HB954 | G-protein coupled receptor AGR9 | RBU-15 |
| Database Links |
|
| Specialist databases | |
| GPCRdb | gp176_human (Hs), gp176_mouse (Mm), gp176_rat (Rn) |
| Other databases | |
| Alphafold | Q14439 (Hs), Q80WT4 (Mm), Q64017 (Rn) |
| ChEMBL Target | CHEMBL4523869 (Hs) |
| Ensembl Gene | ENSG00000166073 (Hs), ENSMUSG00000040133 (Mm), ENSRNOG00000005971 (Rn) |
| Entrez Gene | 11245 (Hs), 381413 (Mm), 117257 (Rn) |
| Human Protein Atlas | ENSG00000166073 (Hs) |
| KEGG Gene | hsa:11245 (Hs), mmu:381413 (Mm), rno:117257 (Rn) |
| OMIM | 612183 |
| Pharos | Q14439 (Hs) |
| RefSeq Nucleotide | NM_007223 (Hs), NM_201367 (Mm), NM_001270986 (Rn) |
| RefSeq Protein | NP_009154 (Hs), NP_958755 (Mm), NP_001257915 (Rn) |
| UniProtKB | Q14439 (Hs), Q80WT4 (Mm), Q64017 (Rn) |
| Wikipedia | GPR176 (Hs) |
| Primary Transduction Mechanisms
|
|
| Transducer | Effector/Response |
| Gi/Go family | |
| Comments: Reported to couple constitutively to Gi [5], to Gz in the suprachiasmatic nucleus [2] and to Gs in colorectal cancer cells [6]. | |
| References: | |
| Tissue Distribution
|
||||||||
|
||||||||
| Tissue Distribution Comments | ||||||||
| Highest levels of expression are seen in human ovary, embryonic and nerve tissues (based on Unigene EST profile). | ||||||||
| Expression Datasets |
|
|
| Physiological Consequences of Altering Gene Expression Comments | |
| Knockout mice appeared superficially normal, but exhibited a shorter circadian period [1]. |
| Biologically Significant Variants
|
||||||||||||||||
|
||||||||||||||||
| Biologically Significant Variant Comments | ||||||||||||||||
| The RefSeq gene (Gene ID:11245) has 3 coding exons, first contains most of TM 1, second contains most of TMs 2 and 3. There are a number of cDNAs which insert an extra 58 base exon between exons 1 and 2 and then use a compensating shorter (by 61 bases at acceptor end) version of exon 2. These alternate splice variants seem to be associated with one allele of the SNP rs66490630 which is the last base of the extra exon. |
1. Doi M, Ishida A, Miyake A, Sato M, Komatsu R, Yamazaki F, Kimura I, Tsuchiya S, Kori H, Seo K et al.. (2011) Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus. Nat Commun, 2: 327. [PMID:21610730]
2. Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW et al.. (2016) Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Nat Commun, 7: 10583. [PMID:26882873]
3. Hata S, Emi Y, Iyanagi T, Osumi T. (1995) cDNA cloning of a putative G protein-coupled receptor from brain. Biochim Biophys Acta, 1261 (1): 121-5. [PMID:7893747]
4. Ishizaka N, Okazaki H, Kurokawa K, Kumada M, Takuwa Y. (1994) Molecular cloning of a novel putative G protein-coupled receptor from rat aortic smooth muscle. Downregulation of the mRNA level by the cyclic AMP messenger pathway. Biochim Biophys Acta, 1218 (2): 173-80. [PMID:8018717]
5. Martin AL, Steurer MA, Aronstam RS. (2015) Constitutive Activity among Orphan Class-A G Protein Coupled Receptors. PLoS One, 10 (9): e0138463. [PMID:26384023]
6. Tang J, Peng W, Ji J, Peng C, Wang T, Yang P, Gu J, Feng Y, Jin K, Wang X et al.. (2023) GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer. Adv Sci (Weinh), 10 (12): e2205627. [PMID:36905238]
