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GPR150

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Not curated in GtoImmuPdb

Target id: 136

Nomenclature: GPR150

Family: Class A Orphans with no pharmacology

Annotation status:  image of a blue circle Annotated and reviewed, awaiting update  » Email us

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 434 5q15 GPR150 G protein-coupled receptor 150
Mouse 7 427 13 C1 Gpr150 G protein-coupled receptor 150
Rat 7 - 2q11 Gpr150 G protein-coupled receptor 150
Previous and Unofficial Names Click here for help
PGR11
Database Links Click here for help
Alphafold Q8NGU9 (Hs), Q8BL07 (Mm)
ChEMBL Target CHEMBL4523898 (Hs)
Ensembl Gene ENSG00000178015 (Hs), ENSMUSG00000045509 (Mm), ENSRNOG00000026944 (Rn)
Entrez Gene 285601 (Hs), 238725 (Mm), 499486 (Rn)
Human Protein Atlas ENSG00000178015 (Hs)
KEGG Gene hsa:285601 (Hs), mmu:238725 (Mm), rno:499486 (Rn)
Pharos Q8NGU9 (Hs)
RefSeq Nucleotide NM_954713 (Hs), NM_175495 (Mm), NM_001109173 (Rn)
RefSeq Protein NP_954713 (Hs), NP_780704 (Mm), NP_001102643 (Rn)
UniProtKB Q8NGU9 (Hs), Q8BL07 (Mm)
Wikipedia GPR150 (Hs)
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gi/Go family
Comments:  Reported to couple constitutively to Gi.
References:  3
Tissue Distribution Click here for help
Central nervous system
Species:  Human
Technique:  Expressed sequence tag
References:  2
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  E214Q
Global MAF (%):  16
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 3|16|17|22
Minor allele count:  C=0.156/341
SNP accession:  rs113272282
Validation:  1000 Genomes
General Comments
Abberant methylation of the GPR150 gene may be a candidate tumor marker [1].

References

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1. Cai LY, Abe M, Izumi S, Imura M, Yasugi T, Ushijima T. (2007) Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. Life Sci, 80 (16): 1458-65. [PMID:17303177]

2. Gloriam DE, Schiöth HB, Fredriksson R. (2005) Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim Biophys Acta, 1722 (3): 235-46. [PMID:15777626]

3. Martin AL, Steurer MA, Aronstam RS. (2015) Constitutive Activity among Orphan Class-A G Protein Coupled Receptors. PLoS One, 10 (9): e0138463. [PMID:26384023]

Citation information

Last modified on 16/07/2025.

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