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GPR149

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Not curated in GtoImmuPdb

Target id: 135

Nomenclature: GPR149

Family: Class A Orphans with no pharmacology

Annotation status:  image of a blue circle Annotated and reviewed, awaiting update  » Email us

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 731 3q25.2 GPR149 G protein-coupled receptor 149
Mouse 7 732 3 E1 Gpr149 G protein-coupled receptor 149
Rat 7 730 2q31 Gpr149 G protein-coupled receptor 149
Previous and Unofficial Names Click here for help
IEDA | G-protein coupled receptor PGR10 | induced early in differentiating astrocytes gene protein
Database Links Click here for help
Alphafold Q86SP6 (Hs), Q3UVY1 (Mm), Q924Y8 (Rn)
ChEMBL Target CHEMBL4523883 (Hs)
Ensembl Gene ENSG00000174948 (Hs), ENSMUSG00000043441 (Mm), ENSRNOG00000014793 (Rn)
Entrez Gene 344758 (Hs), 229357 (Mm), 192251 (Rn)
Human Protein Atlas ENSG00000174948 (Hs)
KEGG Gene hsa:344758 (Hs), mmu:229357 (Mm), rno:192251 (Rn)
Pharos Q86SP6 (Hs)
RefSeq Nucleotide NM_001038705 (Hs), NM_177346 (Mm), NM_138891 (Rn)
RefSeq Protein NP_001033794 (Hs), NP_796320 (Mm), NP_620246 (Rn)
UniProtKB Q86SP6 (Hs), Q3UVY1 (Mm), Q924Y8 (Rn)
Wikipedia GPR149 (Hs)
Tissue Distribution Click here for help
Ovary, brain, digestive tract
Species:  Mouse
Technique:  RT-PCR
References:  1
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression Click here for help
Increased fertility and enhanced ovulation, with increased levels of FSH receptor and cyclin D2 mRNA levels, in receptor knockout mice
Species:  Mouse
Tissue:  Oocytes, granulosa cells
Technique:  Gene knockout
References:  1
GPR149 deficiency reduced oligodendrocyte progenitor cell maturation
Species:  Mouse
Tissue: 
Technique: 
References:  2
Global knockout reduced weight gain in mice fed a high fat diet
Species:  Mouse
Tissue:  Whole animal
Technique:  CRISPR-Cas9
References:  3
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N		 MGI:2443628  MP:0001927 abnormal estrous cycle PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N		 MGI:2443628  MP:0002161 abnormal fertility/fecundity PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N		 MGI:2443628  MP:0005410 abnormal fertilization PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N		 MGI:2443628  MP:0001130 abnormal ovarian folliculogenesis PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N		 MGI:2443628  MP:0001928 abnormal ovulation PMID: 19887567 
Gpr149+|Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149+
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N		 MGI:2443628  MP:0001928 abnormal ovulation PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N		 MGI:2443628  MP:0001934 increased litter size PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N		 MGI:2443628  MP:0008870 increased mature ovarian follicle number PMID: 19887567 
Gpr149tm1.1Zuk Gpr149tm1.1Zuk/Gpr149tm1.1Zuk
involves: 129S7/SvEvBrd * C57BL/6J * FVB/N		 MGI:2443628  MP:0009017 prolonged estrus PMID: 19887567 

References

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1. Edson MA, Lin YN, Matzuk MM. (2010) Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Endocrinology, 151 (1): 358-68. [PMID:19887567]

2. Suo N, He B, Cui S, Yang Y, Wang M, Yuan Q, Xie X. (2022) The orphan G protein-coupled receptor GPR149 is a negative regulator of myelination and remyelination. Glia, 70 (10): 1992-2008. [PMID:35758525]

3. Wyler S, Surbhi, Cao N, Merchant W, Bookout A, Gautron L. (2024) Gpr149 is involved in energy homeostasis in the male mouse. PeerJ, 12: e16739. [PMID:38282864]

Citation information

Last modified on 16/07/2025.

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