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GPR141

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Immunopharmacology Ligand Target has curated data in GtoImmuPdb

Target id: 131

Nomenclature: GPR141

Family: Class A Orphans with no pharmacology

Annotation status:  image of a blue circle Annotated and reviewed, awaiting update  » Email us

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 305 7p14.1 GPR141 G protein-coupled receptor 141
Mouse 7 305 13 A2 Gpr141 G protein-coupled receptor 141
Rat 5 247 17q11 Gpr141 G protein-coupled receptor 141
Previous and Unofficial Names Click here for help
axor115 | G-protein coupled receptor PGR13
Database Links Click here for help
Alphafold Q7Z602 (Hs), Q7TQP0 (Mm), Q7TQN5 (Rn)
ChEMBL Target CHEMBL4523879 (Hs)
Ensembl Gene ENSG00000187037 (Hs), ENSMUSG00000053101 (Mm), ENSRNOG00000066332 (Rn), ENSRNOG00000059698 (Rn)
Entrez Gene 353345 (Hs), 353346 (Mm), 291179 (Rn)
Human Protein Atlas ENSG00000187037 (Hs)
KEGG Gene hsa:353345 (Hs), mmu:353346 (Mm), rno:291179 (Rn)
OMIM 609045 (Hs)
Pharos Q7Z602 (Hs)
RefSeq Nucleotide NM_181791 (Hs), NM_181754 (Mm), NM_181767 (Rn)
RefSeq Protein NP_861456 (Hs), NP_861419 (Mm), NP_861432 (Rn)
UniProtKB Q7Z602 (Hs), Q7TQP0 (Mm), Q7TQN5 (Rn)
Wikipedia GPR141 (Hs)
Immunopharmacology Comments
May function as an inflammation suppressor in myeloid cells [2].
Tissue Distribution Click here for help
Marrow, cancer cells such as human fibrosarcoma HT1080 cells
Species:  Human
Technique:  Expressed sequence tag
References:  1
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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References

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1. Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2003) Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett, 554 (3): 381-8. [PMID:14623098]

2. Sawabe A, Okazaki S, Nakamura A, Goitsuka R, Kaifu T. (2024) The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor. J Leukoc Biol, 115 (5): 935-945. [PMID:38226682]

Citation information

Last modified on 16/07/2025.

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