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Not curated in GtoImmuPdb
Target id: 111
Nomenclature: GPR62
Family: Class A Orphans with no pharmacology
Annotation status:
Annotated and reviewed, awaiting update
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Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 368 | 3p21.2 | GPR62 | G protein-coupled receptor 62 | 2 |
| Mouse | 7 | 358 | 9 F1 | Gpr62 | G protein-coupled receptor 62 | |
| Rat | - | 358 | 8q32 | Gpr62 | G protein-coupled receptor 62 | |
| Previous and Unofficial Names |
| GPCR8 |
| Database Links |
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| Specialist databases | |
| GPCRdb | gpr62_human (Hs), gpr62_mouse (Mm), d4a2b1_rat (Rn) |
| Other databases | |
| Alphafold | Q9BZJ7 (Hs), Q80UC6 (Mm), D4A2B1 (Rn) |
| ChEMBL Target | CHEMBL4523917 (Hs) |
| Ensembl Gene | ENSG00000180929 (Hs), ENSMUSG00000091735 (Mm), ENSRNOG00000022567 (Rn) |
| Entrez Gene | 118442 (Hs), 436090 (Mm), 501049 (Rn) |
| Human Protein Atlas | ENSG00000180929 (Hs) |
| KEGG Gene | hsa:118442 (Hs), mmu:436090 (Mm), rno:501049 (Rn) |
| OMIM | 606917 (Hs) |
| Pharos | Q9BZJ7 (Hs) |
| RefSeq Nucleotide | NM_080865 (Hs), NM_001159652 (Mm), XM_576464 (Rn) |
| RefSeq Protein | NP_543141 (Hs), NP_001153124 (Mm), XP_576464 (Rn) |
| UniProtKB | Q9BZJ7 (Hs), Q80UC6 (Mm), D4A2B1 (Rn) |
| Wikipedia | GPR62 (Hs) |
| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gs family | |
| Comments: Reported to couple constitutively to Gs | |
| References: 3 | |
| Tissue Distribution
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| Tissue Distribution Comments | ||||||||
| Transcripts of GPR62 were not detected in the liver when examined by Northern blot analysis [2]. | ||||||||
| Physiological Consequences of Altering Gene Expression Comments | |
| No overt phenotype [3] or impact on CNS myelination [1]. |
| Biologically Significant Variants
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| General Comments |
| GPR62 has higher expression in the brain, indicating its cognate ligand may be a neurotransmitter [2]. |
1. Hay CM, Jackson S, Mitew S, Scott DJ, Koenning M, Bensen AL, Bujalka H, Kilpatrick TJ, Emery B. (2021) The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination. Neural Dev, 16 (1): 6. [PMID:34844642]
2. Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF. (2001) Identification of four novel human G protein-coupled receptors expressed in the brain. Brain Res Mol Brain Res, 86 (1-2): 13-22. [PMID:11165367]
3. Muroi T, Matsushima Y, Kanamori R, Inoue H, Fujii W, Yogo K. (2017) GPR62 constitutively activates cAMP signaling but is dispensable for male fertility in mice. Reproduction, 154 (6): 755-764. [PMID:28912303]
