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GPR45

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Not curated in GtoImmuPdb

Target id: 106

Nomenclature: GPR45

Family: Class A Orphans with no pharmacology

Annotation status:  image of a blue circle Annotated and reviewed, awaiting update  » Email us

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 372 2q12.1 GPR45 G protein-coupled receptor 45 2
Mouse 7 373 1 B Gpr45 G protein-coupled receptor 45
Rat 7 373 9q22 Gpr45 G protein-coupled receptor 45
Previous and Unofficial Names Click here for help
PSP24 | high-affinity lysophosphatidic acid receptor | PSP24alpha | PSP24A
Database Links Click here for help
Specialist databases
GPCRdb gpr45_human (Hs), gpr45_mouse (Mm)
Other databases
Alphafold Q9Y5Y3 (Hs), Q9EQQ4 (Mm)
ChEMBL Target CHEMBL4523928 (Hs)
Ensembl Gene ENSG00000135973 (Hs), ENSMUSG00000041907 (Mm), ENSRNOG00000016446 (Rn)
Entrez Gene 11250 (Hs), 93690 (Mm), 301372 (Rn)
Human Protein Atlas ENSG00000135973 (Hs)
KEGG Gene hsa:11250 (Hs), mmu:93690 (Mm), rno:301372 (Rn)
OMIM 604838 (Hs)
Pharos Q9Y5Y3 (Hs)
RefSeq Nucleotide NM_007227 (Hs), NM_053107 (Mm), NM_001106906 (Rn)
RefSeq Protein NP_009158 (Hs), NP_444337 (Mm), NP_001100376 (Rn)
UniProtKB Q9Y5Y3 (Hs), Q9EQQ4 (Mm)
Wikipedia GPR45 (Hs)
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gs family
Gi/Go family
References:  3-4
Tissue Distribution Click here for help
Basal forebrain, frontal cortex, caudate, liver
Species:  Human
Technique:  Northern blot
References:  2
Neuronal cells, such as olfactory mitral cells, cortical neurons, hippocampal pyramidal cells, purkinje cells in the cerebellum
Species:  Mouse
Technique:  in situ hybridisation
References:  1
Brain
Species:  Mouse
Technique:  Northern blot
References:  1
Tissue Distribution Comments
No transcripts of GPR45 were detected in thalamus, hippocampus or putamen [2]. The expression of GPR45 in mouse brain starts from E13 and remains constant throughout adulthood [1].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  L312F
Global MAF (%):  10
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 5|12|2|16
Minor allele count:  T=0.096/209
SNP accession:  VAR_049394, rs35946826
Validation:  1000 Genomes, HapMap

References

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1. Kawasawa Y, Kume K, Nakade S, Haga H, Izumi T, Shimizu T. (2000) Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Biochem Biophys Res Commun, 276 (3): 952-6. [PMID:11027574]

2. Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF. (1999) Discovery of three novel orphan G-protein-coupled receptors. Genomics, 56 (1): 12-21. [PMID:10036181]

3. Martin AL, Steurer MA, Aronstam RS. (2015) Constitutive Activity among Orphan Class-A G Protein Coupled Receptors. PLoS One, 10 (9): e0138463. [PMID:26384023]

4. Xun Y, Jiang Y, Xu B, Tang M, Ludwig S, Nakamura K, Mukhopadhyay S, Liu C, Beutler B, Zhang Z. (2025) GPR45 modulates Gαs at primary cilia of the paraventricular hypothalamus to control food intake. Science, 388 (6751): eadp3989. [PMID:40472089]

Citation information

Last modified on 16/07/2025.

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