GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

IL-23   Click here for help

GtoPdb Ligand ID: 4978

Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-23 is an IL-12 family cytokine. Structurally it is a heterodimer consisting of IL-12B and IL-23A subunits.
Species: Human
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
References
1. Bloch Y, Bouchareychas L, Merceron R, Składanowska K, Van den Bossche L, Detry S, Govindarajan S, Elewaut D, Haerynck F, Dullaers M et al.. (2018)
Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1.
Immunity, 48 (1): 45-58.e6. [PMID:29287995]
2. Gee K, Guzzo C, Che Mat NF, Ma W, Kumar A. (2009)
The IL-12 family of cytokines in infection, inflammation and autoimmune disorders.
Inflamm Allergy Drug Targets, 8 (1): 40-52. [PMID:19275692]
3. Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ. (2004)
IL-12 and IL-23: master regulators of innate and adaptive immunity.
Immunol Rev, 202: 96-105. [PMID:15546388]
4. Lay CS, Bridges A, Goulding J, Briddon SJ, Soloviev Z, Craggs PD, Hill SJ. (2022)
Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET.
Cell Chem Biol, 29 (1): 19-29.e6. [PMID:34038748]
5. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F et al.. (2002)
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
J Immunol, 168 (11): 5699-708. [PMID:12023369]
6. Tang C, Chen S, Qian H, Huang W. (2012)
Interleukin-23: as a drug target for autoimmune inflammatory diseases.
Immunology, 135 (2): 112-24. [PMID:22044352]