pacibekitug

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Ligands
pacibekitug

GtoPdb Ligand ID: 14206

Synonyms: PF 4236921 | PF-4236921 | PF04236921 | TOUR-006 | TOUR006

Compound class: Antibody

Comment: Pacibekitug (TOUR006; formerly PF-04236921) is a fully human IgG2 anti-IL-6 monoclonal antibody. It binds to and neutralises IL-6 activity. The peptides comprising pacibekitug are claimed in patent WO2009155180A1, and constitute the clone described as 9C8 N68T T83S therein [3].

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
IL-6 promotes production of C-reactive protein in the liver. Pacibekitug reduces serum C-reactive protein in clinical studies, and this can be used as a marker of antibody-target engagement [2].

Immunopharmacology Comments

IL-6 promotes production of C-reactive protein in the liver. Pacibekitug reduces serum C-reactive protein in clinical studies, and this can be used as a marker of antibody-target engagement [2].