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pacibekitug   Click here for help

GtoPdb Ligand ID: 14206

Synonyms: PF 4236921 | PF-4236921 | PF04236921 | TOUR-006 | TOUR006
Immunopharmacology Ligand
Compound class: Antibody
Comment: Pacibekitug (TOUR006; formerly PF-04236921) is a fully human IgG2 anti-IL-6 monoclonal antibody. It binds to and neutralises IL-6 activity. The peptides comprising pacibekitug are claimed in patent WO2009155180A1, and constitute the clone described as 9C8 N68T T83S therein [3].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-6 Hs Antibody Binding 9.9 pKd - 3
⤷ pKd 9.9 (Kd 1.35x10-10 M) [3]
Description: Binding affinity for IL-6 determined by SPR