FAM150B

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

Home
Ligands
FAM150B (Human)

GtoPdb Ligand ID: 14204

Synonyms: ALKAL2 | AUG-α | augmentor-α | augmentor-alpha

Compound class: Endogenous peptide in human, mouse or rat

Comment: FAM150B (AUG-α) is an endogenous leukocyte receptor tyrosine kinase (LTK) and ALK receptor tyrosine kinase (ALK) activating ligand [1-2].

Species: Human

References
1. Guan J, Umapathy G, Yamazaki Y, Wolfstetter G, Mendoza P, Pfeifer K, Mohammed A, Hugosson F, Zhang H, Hsu AW et al.. (2015) FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase. Elife, 4: e09811. [PMID:26418745]
2. Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, Bai H, Gunel M, Lax I, Schlessinger J. (2015) Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions. Proc Natl Acad Sci U S A, 112 (52): 15862-7. [PMID:26630010]

References

1. Guan J, Umapathy G, Yamazaki Y, Wolfstetter G, Mendoza P, Pfeifer K, Mohammed A, Hugosson F, Zhang H, Hsu AW et al.. (2015)
FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.
Elife, 4: e09811. [PMID:26418745]

2. Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, Bai H, Gunel M, Lax I, Schlessinger J. (2015)
Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.
Proc Natl Acad Sci U S A, 112 (52): 15862-7. [PMID:26630010]