gruticibart

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

Home
Ligands
gruticibart

GtoPdb Ligand ID: 14082

Synonyms: AB-023 | AB023 | xisomab 3G3

Compound class: Antibody

Comment: Gruticibart (formerly Xisomab 3G3 and AB023) is an antibody that binds factor XI and blocks its activation by activated FXII [1]. It does not block thrombin-mediated FXI activation.

Summary
Biological activity
Clinical data
References

References
1. Lorentz CU, Tucker EI, Verbout NG, Shatzel JJ, Olson SR, Markway BD, Wallisch M, Ralle M, Hinds MT, McCarty OJT et al.. (2021) The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial. Blood, 138 (22): 2173-2184. [PMID:34086880]

References

1. Lorentz CU, Tucker EI, Verbout NG, Shatzel JJ, Olson SR, Markway BD, Wallisch M, Ralle M, Hinds MT, McCarty OJT et al.. (2021)
The contact activation inhibitor AB023 in heparin-free hemodialysis: results of a randomized phase 2 clinical trial.
Blood, 138 (22): 2173-2184. [PMID:34086880]