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gruticibart   Click here for help

GtoPdb Ligand ID: 14082

Synonyms: AB-023 | AB023 | xisomab 3G3
Compound class: Antibody
Comment: Gruticibart (formerly Xisomab 3G3 and AB023) is an antibody that binds factor XI and blocks its activation by activated FXII [1]. It does not block thrombin-mediated FXI activation.
No information available.
Summary of Clinical Use Click here for help
Xisomab 3G3 (AB023) was advanced to clinical trial as an antithrombotic agent.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03097341 Safety and Tolerability Study of Xisomab 3G3 in Healthy Adult Subjects Phase 1 Interventional Aronora, Inc.
NCT03612856 Safety and Efficacy Study of AB023 (Xisomab 3G3) in End Stage Renal Disease Patients on Chronic Hemodialysis Phase 2 Interventional Aronora, Inc. 1