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gruticibart   Click here for help

GtoPdb Ligand ID: 14082

Synonyms: AB-023 | AB023 | xisomab 3G3
Compound class: Antibody
Comment: Gruticibart (formerly Xisomab 3G3 and AB023) is an antibody that binds factor XI and blocks its activation by activated FXII [1]. It does not block thrombin-mediated FXI activation.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
coagulation factor XI Hs Antibody Inhibition - - - 1
⤷ [1]