fesomersen

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Ligands
fesomersen

GtoPdb Ligand ID: 14081

Synonyms: IONIS-FXI-LRx

Compound class: Nucleic acid

Comment: Fesomersen (IONIS-FXI-LRx) is a conjugated antisense oligonucleotide that selectively inhibits the expression of factor XI [1]. It is being explored as an anticoagulation therapy.
We provide the basic nucleotide sequence, without the modifications outlined in the INN record for this drug.

Summary
Biological activity
Clinical data
References
Structure

References
1. Liu T, Hashizume K, Krieg E, Chen H, Mukaida Y, Thelen K, Friedrichs F, Willmann S, Schwers S, Solms A et al.. (2024) Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers. Clin Transl Sci, 17 (4): e13784. [PMID:38563414]

References

1. Liu T, Hashizume K, Krieg E, Chen H, Mukaida Y, Thelen K, Friedrichs F, Willmann S, Schwers S, Solms A et al.. (2024)
Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers.
Clin Transl Sci, 17 (4): e13784. [PMID:38563414]