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sonvuterkib   Click here for help

GtoPdb Ligand ID: 14074

Compound class: Synthetic organic
Comment: Sonvuterkib is the INN for an extracellular signal-regulated kinases (ERK) inhibitor that was included in WHO INN proposed list 133 (10th July 2025). It is claimed as compound WX001 in patent WO2023274256A1, principally to target Ras/Raf/MEK/ERK pathway activation in tumours [1]. Sonvuterkib is potentially the INN for D3 Bio's dual ERK1/2 inhibitor clinical lead D3S-002 (structure not disclosed, July 2025).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 131.91
Molecular weight 474.54
XLogP -1.17
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC1=CN=C(NC2=CC=NN2C)N=C1C3=NC4=C(C5(COC5)N(CC6=NC(=CC=C6)C)C4=O)S3
Isomeric SMILES CC1=NC(=CC=C1)CN2C(=O)C3=C(C24COC4)SC(=N3)C5=NC(=NC=C5C)NC6=CC=NN6C
InChI InChI=1S/C23H22N8O2S/c1-13-9-24-22(27-16-7-8-25-30(16)3)29-17(13)20-28-18-19(34-20)23(11-33-12-23)31(21(18)32)10-15-6-4-5-14(2)26-15/h4-9H,10-12H2,1-3H3,(H,24,27,29)
InChI Key XDQJPNLCRUUTCE-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
No information available.
Summary of Clinical Use Click here for help
D3S-002 has progressed to clinical trial. It will be investigated for safety and efficacy in patients with advanced solid tumours with MAPK pathway activation.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT05886920 Study of D3S-002 as Monotherapy in Adult Subjects With Advanced Solid Tumors With MAPK Pathway Mutations Phase 1 Interventional D3 Bio (Wuxi) Co., Ltd