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Compound class:
Antibody
Comment: Camelid nanobody NB32 is reported as a negative allosteric modulator of the human calcium sensing receptor [1]. It disrupts receptor dimerisation and stabilises the receptor in its inactive state.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Cui Q, Wang L, Wang H, Chen X, Han L, Geng T, Kou Y, Zhang W, Dai M, Qiao H et al.. (2024)
Nanobodies as negative allosteric modulators for human calcium sensing receptor. Biochem Biophys Res Commun, 695: 149401. [PMID:38154264] |
