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domvanalimab   Click here for help

GtoPdb Ligand ID: 13983

Synonyms: AB-154 | AB154
Immunopharmacology Ligand
Compound class: Antibody
Comment: Domvanalimab (AB154) is an anti-TIGIT monoclonal antibody. It is designed to be 'Fc-silent' as a method to prevent depletiion of regulatory T cells (which would otherwise be promoted by Fc-mediated antibody dependent cellular cytotoxicity). Silencing TIGIT has two functions. It negates the inhibitory action of TIGIT binding to poliovirus receptor (PVR, CD155) which blocks immune suppression, and it leaves PVR available to interact with the costimulatory DNAM-1 (CD226) molecule. The combined effects potentiate a natural killer (NK) cell and T cell-mediated anti-tumour immune response.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
11559 domvanalimab
Synonyms Click here for help
AB-154 | AB154
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1125
Other databases
Search PubMed clinical trials domvanalimab
Search PubMed titles domvanalimab
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