GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

zaloblideg   Click here for help

GtoPdb Ligand ID: 13460

Synonyms: ARV-393 | ARV393 | compound 81 [WO2022221673A1]
Compound class: Synthetic organic
Comment: ARV-393 is an orally active PROTAC that promotes degradation of the BCL6 transcription repressor protein. A lenalidomide derived moiety promotes formation of a ternary complex of the PROTAC, target protein and the E3 ligase cereblon to induce ubiquitination and degradation. The structure shown here has (1r,3r) configuration around the cyclobutoxy group, as indicated for compound 81 in Arvinas' patent WO2022221673A [1]. We will update this entry whenever ARV-393's chemical structure is formally disclosed.
BCL6 is a transcriptional repressor and major driver of B-cell lymphomas. Reducing BCL6 activity or abundance are proposed as mechanisms to treat advanced B-cell malignancies such as non-Hodgkin's lymphoma.
In July 2025 we were able to match the structure of ARV-393 to the INN zaloblideg that was included in WHO INN proposed list 133.

zaloblideg is commercially available from our sponsors

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 16
Hydrogen bond donors 3
Rotatable bonds 13
Topological polar surface area 177.58
Molecular weight 898.42
XLogP 1.33
No. Lipinski's rules broken 3

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES CC(C)N1C2=C(C=C(C=C2)NC3=C(C=NC(=N3)N4CCC(CC4)O[C@H]5C[C@@H](C5)N6CCC(CC6)C7=CC=C8C(=C7F)CN(C9CCC(=O)NC9=O)C8=O)Cl)C=C(C1=O)OCC(=O)NC
Isomeric SMILES CNC(=O)COC1=CC2=C(C=CC(NC3=C(Cl)C=NC(=N3)N4CCC(CC4)O[C@H]5C[C@@H](C5)N6CCC(CC6)C7=CC=C8C(=O)N(CC8=C7F)C9CCC(=O)NC9=O)=C2)N(C(C)C)C1=O
InChI InChI=1S/C46H53ClFN9O7/c1-25(2)57-36-7-4-28(18-27(36)19-38(45(57)62)63-24-40(59)49-3)51-42-35(47)22-50-46(53-42)55-16-12-30(13-17-55)64-31-20-29(21-31)54-14-10-26(11-15-54)32-5-6-33-34(41(32)48)23-56(44(33)61)37-8-9-39(58)52-43(37)60/h4-7,18-19,22,25-26,29-31,37H,8-17,20-21,23-24H2,1-3H3,(H,49,59)(H,50,51,53)(H,52,58,60)/t29-,31-,37?
InChI Key ZOGOEUHUEFKKTD-VVDHFOCHSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders
International Nonproprietary Names Click here for help
INN number INN
13762 zaloblideg
Synonyms Click here for help
ARV-393 | ARV393 | compound 81 [WO2022221673A1]
Database Links Click here for help
CAS Registry No. 2851885-95-3 (source: WHO INN record)
GtoPdb PubChem SID 500839870
PubChem CID 166077922
Search Google for chemical match using the InChIKey ZOGOEUHUEFKKTD-VVDHFOCHSA-N
Search Google for chemicals with the same backbone ZOGOEUHUEFKKTD
Search PubMed clinical trials zaloblideg
Search PubMed titles zaloblideg
Search PubMed titles/abstracts zaloblideg
UniChem Compound Search for chemical match using the InChIKey ZOGOEUHUEFKKTD-VVDHFOCHSA-N
UniChem Connectivity Search for chemical match using the InChIKey ZOGOEUHUEFKKTD-VVDHFOCHSA-N

Product suppliers

View disclaimer

Sponsored products disclaimer

Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

✖

MedChemExpress
ARV-393 (links to external site)
Cat. No. HY-158105