mutant ANP

GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

Home
Ligands
mutant ANP

GtoPdb Ligand ID: 10211

Synonyms: mANP | mutant atrial natriuretic peptide

Compound class: Peptide

Comment: This is a naturally occurring variant of human atrial natriuretic peptide (ANP) [2]. It is a fusion protein that contains the full 28 amino acids of ANP plus a 12 amino acid C-terminal extension. In comparison to normal ANP this longer peptide exhibits enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions in vivo.

References
1. Chen Y, Schaefer JJ, Iyer SR, Harders GE, Pan S, Sangaralingham SJ, Chen HH, Redfield MM, Burnett Jr JC. (2020) Long-term blood pressure lowering and cGMP-activating actions of the novel ANP analog MANP. Am J Physiol Regul Integr Comp Physiol, 318 (4): R669-R676. [PMID:32022596]
2. Hodgson-Zingman DM, Karst ML, Zingman LV, Heublein DM, Darbar D, Herron KJ, Ballew JD, de Andrade M, Burnett Jr JC, Olson TM. (2008) Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation. N Engl J Med, 359 (2): 158-65. [PMID:18614783]
3. McKie PM, Cataliotti A, Huntley BK, Martin FL, Olson TM, Burnett Jr JC. (2009) A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions. J Am Coll Cardiol, 54 (11): 1024-32. [PMID:19729120]

References

1. Chen Y, Schaefer JJ, Iyer SR, Harders GE, Pan S, Sangaralingham SJ, Chen HH, Redfield MM, Burnett Jr JC. (2020)
Long-term blood pressure lowering and cGMP-activating actions of the novel ANP analog MANP.
Am J Physiol Regul Integr Comp Physiol, 318 (4): R669-R676. [PMID:32022596]

2. Hodgson-Zingman DM, Karst ML, Zingman LV, Heublein DM, Darbar D, Herron KJ, Ballew JD, de Andrade M, Burnett Jr JC, Olson TM. (2008)
Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation.
N Engl J Med, 359 (2): 158-65. [PMID:18614783]

3. McKie PM, Cataliotti A, Huntley BK, Martin FL, Olson TM, Burnett Jr JC. (2009)
A human atrial natriuretic peptide gene mutation reveals a novel peptide with enhanced blood pressure-lowering, renal-enhancing, and aldosterone-suppressing actions.
J Am Coll Cardiol, 54 (11): 1024-32. [PMID:19729120]