AMG410 [Ligand Id: 14131] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| KRAS in Human [GtoPdb: 2824] [UniProtKB: P01116] | ||||||||
| GtoPdb | Binding affinity for GTP-bound (on state) KRAS | - | 7.66 | pKd | 22 | nM | Kd | ND01 - AMG 410: An H/NRAS-sparing pan-KRAS inhibitor with dual GTP(on)/GDP(off)-state activity for the treatment of diverse KRAS-mutant tumors. abstractsonline.com |
| GtoPdb | Binding affinity for GDP-bound (off state) KRAS | - | 9 | pKd | 1 | nM | Kd | WO2024107686A1. Macrocyclic KRAS inhibitors and methods of use (2024) |
| GtoPdb | Binding IC50 for hKRASG12D | - | 8.52 | pIC50 | 3 | nM | IC50 | WO2024107686A1. Macrocyclic KRAS inhibitors and methods of use (2024) |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
