aceclidine [Ligand Id: 14102] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL20835 (3-quinuclidinol acetate (ester), 3-quinuclidinol dl-form acetate (ester), Aceclidina, Aceclidine, Aceclidine hcl, Aceclidine hydrochloride, NSC-657843, NSC-758239) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| ChEMBL | Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholine receptor M1. | F | 5.35 | pEC50 | 4466 | nM | EC50 | J Med Chem (1998) 41: 379-392 [PMID:9464368] |
| M1 receptor/Muscarinic acetylcholine receptor M1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482] | ||||||||
| ChEMBL | Binding affinity for muscarinic acetylcholine receptor M1 using [3H]pirenzepine (Pz) radioligand in rat hippocampus membranes. | B | 5.61 | pIC50 | 2427 | nM | IC50 | J Med Chem (1998) 41: 379-392 [PMID:9464368] |
| ChEMBL | Binding affinity for muscarinic acetylcholine receptor M1 using [3H]oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes | B | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (1998) 41: 379-392 [PMID:9464368] |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5105] [GtoPdb: 15] [UniProtKB: Q9ERZ3] | ||||||||
| ChEMBL | Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell line | F | 5 | pEC50 | 10000 | nM | EC50 | J Med Chem (1997) 40: 1230-1246 [PMID:9111297] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
