compound E3 [Ligand Id: 14091] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Erythrocyte urea transporter in Human [GtoPdb: 982] [UniProtKB: Q13336] | ||||||||
| GtoPdb | Determined as inhibition of UT-B-promoted urea transport in the red blood cell lysis assay | - | 7.6 | pIC50 | 25 | nM | IC50 |
Biomedicines (2025) 13: [PMID:40299675]; Acta Pharmacol Sin (2025) null: null [PMID:40523902] |
| Erythrocyte urea transporter in Mouse [GtoPdb: 982] [UniProtKB: Q8VHL0] | ||||||||
| GtoPdb | Determined as inhibition of UT-B-promoted urea transport in the red blood cell lysis assay | - | 7.32 | pIC50 | 47.7 | nM | IC50 |
Biomedicines (2025) 13: [PMID:40299675]; Acta Pharmacol Sin (2025) null: null [PMID:40523902] |
| Erythrocyte urea transporter in Rat [GtoPdb: 982] [UniProtKB: P97689] | ||||||||
| GtoPdb | Determined as inhibition of UT-B-promoted urea transport in the red blood cell lysis assay | - | 8.12 | pIC50 | 7.6 | nM | IC50 |
Biomedicines (2025) 13: [PMID:40299675]; Acta Pharmacol Sin (2025) null: null [PMID:40523902] |
| Kidney urea transporter in Human [GtoPdb: 983] [UniProtKB: Q15849] | ||||||||
| GtoPdb | Measured as inhibition of UT-A1-mediated urea permeability in MDCK cell lines stably expressing rat UT-A1, determined in a transwell assay | - | 7.72 | pIC50 | 19 | nM | IC50 |
Biomedicines (2025) 13: [PMID:40299675]; Acta Pharmacol Sin (2025) null: null [PMID:40523902] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
