ICA-121431 [Ligand Id: 14012] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3617053 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Nav1.1/Sodium channel protein type I alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1845] [GtoPdb: 578] [UniProtKB: P35498] | ||||||||
| ChEMBL | Inhibition of human NaV1.1 | B | 7.49 | pIC50 | 32 | nM | IC50 | Medchemcomm (2017) 8: 1255-1267 [PMID:30108836] |
| ChEMBL | Inhibition of human NaV1.1 channel by patch clamp electrophysiology assay | B | 7.7 | pIC50 | <20 | nM | IC50 | J Med Chem (2015) 58: 7093-7118 [PMID:25927480] |
| GtoPdb | - | - | 7.72 | pIC50 | 19 | nM | IC50 | Proc Natl Acad Sci U S A (2013) 110: E2724-32 [PMID:23818614] |
| Nav1.2/Sodium channel protein type II alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4187] [GtoPdb: 579] [UniProtKB: Q99250] | ||||||||
| ChEMBL | Inhibition of human NaV1.2 | B | 6.41 | pIC50 | 393 | nM | IC50 | Medchemcomm (2017) 8: 1255-1267 [PMID:30108836] |
| ChEMBL | Inhibition of human NaV1.2 channel by patch clamp electrophysiology assay | B | 6.62 | pIC50 | 240 | nM | IC50 | J Med Chem (2015) 58: 7093-7118 [PMID:25927480] |
| Nav1.3/Sodium channel protein type III alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5163] [GtoPdb: 580] [UniProtKB: Q9NY46] | ||||||||
| ChEMBL | Inhibition of human TTX-sensitive NaV1.3 channel expressed in HEK293 cells by patch clamp electrophysiology assay | B | 7.7 | pIC50 | <20 | nM | IC50 | J Med Chem (2015) 58: 7093-7118 [PMID:25927480] |
| GtoPdb | - | - | 7.72 | pIC50 | 19 | nM | IC50 | Proc Natl Acad Sci U S A (2013) 110: E2724-32 [PMID:23818614] |
| ChEMBL | Inhibition of human NaV1.3 expressed in HEK cells by electrophysiological method | B | 7.77 | pIC50 | 17 | nM | IC50 | Medchemcomm (2017) 8: 1255-1267 [PMID:30108836] |
| Nav1.3/Sodium channel protein type III alpha subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4966] [GtoPdb: 580] [UniProtKB: P08104] | ||||||||
| ChEMBL | Inhibition of rat NaV1.3 by electrophysiological method | B | 8.22 | pIC50 | 6 | nM | IC50 | Medchemcomm (2017) 8: 1255-1267 [PMID:30108836] |
| Nav1.4/Sodium channel protein type IV alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2072] [GtoPdb: 581] [UniProtKB: P35499] | ||||||||
| ChEMBL | Inhibition of human NaV1.4 channel by patch clamp electrophysiology assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7093-7118 [PMID:25927480] |
| ChEMBL | Inhibition of human NaV1.4 | B | 5 | pIC50 | 10000 | nM | IC50 | Medchemcomm (2017) 8: 1255-1267 [PMID:30108836] |
| Nav1.7/Sodium channel protein type IX alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296] [GtoPdb: 584] [UniProtKB: Q15858] | ||||||||
| ChEMBL | Inhibition of human NaV1.7 channel expressed in HEK293 cells by patch clamp electrophysiology assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7093-7118 [PMID:25927480] |
| ChEMBL | Inhibition of human NaV1.7 | B | 5.28 | pIC50 | 5200 | nM | IC50 | Medchemcomm (2017) 8: 1255-1267 [PMID:30108836] |
| Nav1.7/Sodium channel protein type IX alpha subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3312] [GtoPdb: 584] [UniProtKB: O08562] | ||||||||
| ChEMBL | Inhibition of rat NaV1.7 | B | 7.17 | pIC50 | 68 | nM | IC50 | Medchemcomm (2017) 8: 1255-1267 [PMID:30108836] |
| Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
| ChEMBL | Inhibition of human NaV1.5 channel expressed in HEK293 cells by patch clamp electrophysiology assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7093-7118 [PMID:25927480] |
| ChEMBL | Inhibition of human NaV1.5 | B | 5.04 | pIC50 | 9200 | nM | IC50 | Medchemcomm (2017) 8: 1255-1267 [PMID:30108836] |
| Nav1.6/Sodium channel protein type VIII alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5202] [GtoPdb: 583] [UniProtKB: Q9UQD0] | ||||||||
| ChEMBL | Inhibition of human NaV1.6 | B | 4.99 | pIC50 | 10300 | nM | IC50 | Medchemcomm (2017) 8: 1255-1267 [PMID:30108836] |
| ChEMBL | Inhibition of human NaV1.6 channel by patch clamp electrophysiology assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7093-7118 [PMID:25927480] |
| Nav1.8/Sodium channel protein type X alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5451] [GtoPdb: 585] [UniProtKB: Q9Y5Y9] | ||||||||
| ChEMBL | Inhibition of human NaV1.8 channel by patch clamp electrophysiology assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2015) 58: 7093-7118 [PMID:25927480] |
| ChEMBL | Inhibition of human NaV1.8 | B | 5.52 | pIC50 | 3000 | nM | IC50 | Medchemcomm (2017) 8: 1255-1267 [PMID:30108836] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
