BAY-7598 [Ligand Id: 13973] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4585243 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MMP10/Matrix metalloproteinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4270] [GtoPdb: 1634] [UniProtKB: P09238] | ||||||||
| ChEMBL | Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP10 | B | 7.89 | pIC50 | 13 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| MMP12/Matrix metalloproteinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4393] [GtoPdb: 1636] [UniProtKB: P39900] | ||||||||
| GtoPdb | Binding affinity determined by SPR | - | 11.4 | pKd | 0 | nM | Kd | Overview for BAY-7598 an inhibitor of MMP12. thesgc.org |
| GtoPdb | - | - | 10.07 | pIC50 | 0.09 | nM | IC50 | Overview for BAY-7598 an inhibitor of MMP12. thesgc.org |
| ChEMBL | Biochemical assay (MMP12) | B | 10.07 | pIC50 | 0.09 | nM | IC50 | Data for DCP probe BAY-7598 |
| ChEMBL | Affinity Biochemical interaction (Biochemical assay (inhibition of human macrophage elastase (HME/hMMP-12), addition of 2% BSA)) EUB0000728a MMP12 | B | 10.07 | pIC50 | 0.09 | nM | IC50 | Affinity Biochemical Literature for EUbOPEN Chemogenomics Library wave 3 |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP13 | B | 7.17 | pIC50 | 67 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP14 | B | 6.6 | pIC50 | 250 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512] | ||||||||
| ChEMBL | Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP16 | B | 6.03 | pIC50 | 940 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP2 | B | 7.36 | pIC50 | 44 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP3 | B | 6.44 | pIC50 | 360 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP7 | B | 6.22 | pIC50 | 600 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP8 | B | 7.82 | pIC50 | 15 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP9 | B | 6.34 | pIC50 | 460 | nM | IC50 | Selectivity Literature for EUbOPEN Chemogenomics Library wave 3 |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
