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Type II receptor serine/threonine kinases C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
Type II protein receptor serine/threonine kinases interact with transforming growth factor beta (TGFβ), bone morphogenic protein (BMP) or MÀllerian inhibiting substrate (MIS). Type II RSTKs then phosphorylate the kinase domain of their Type I RSTK partner - sometimes referred to as the signal propagating unit. This causes displacement of protein partners, such as the FKBP12 FK506-binding protein FKBP1A (P62942) and allowing the binding and phosphorylation of particular members of the Smad family.
Receptors
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ActR2 (activin A receptor type 2A)
C
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ActR2B (activin A receptor type 2B)
C
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MISR2 (anti-Mullerian hormone receptor type 2)
C
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BMPR2 (bone morphogenetic protein receptor type 2)
C
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TGFBR2 (transforming growth factor beta receptor 2)
C
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Further reading
Citation information
Database page citation:
Chloe J. Peach. Type II receptor serine/threonine kinases. Accessed on 12/09/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=319.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.
